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Table 2 List of diagnosis clusters from Fig. 2 sorted by their presence in migraine patients (2.5–20% prevalence) and compared to controls. Fold change column shows the prevalence in migraineurs divided by the prevalence in controls. All fold changes are greater than 1 indicating that migraine is associated with higher multimorbidity compared to controls. Due to high sample size, the difference in prevalence between migraineurs and controls is statistically significant (p < 0.001) for each diagnosis

From: Burden of migraine in Finland: multimorbidity and phenotypic disease networks in occupational healthcare

CodeMigraine clusterControl clusterNameM (%)C (%)Fold change
A08M1N/AViral and other specified intestinal infections4.101.802.28
E03M1C4Other hypothyroidism5.203.301.58
F32M1C4Depressive episode13.007.101.83
F33M1N/ARecurrent depressive disorder4.802.501.92
F41M1C4Other anxiety disorders14.107.901.78
F43M1C4Reaction to severe stress, and adjustment disorders17.409.901.76
F51M1C4Nonorganic sleep disorders17.408.801.98
G44M1C4Other headache syndromes19.505.903.31
G47M1N/ASleep disorders4.602.401.92
H04M1C1Disorders of lacrimal system4.102.501.64
H10M1C1Conjunctivitis16.2011.001.47
H81M1N/ADisorders of vestibular function4.502.301.96
I49M1C1Other cardiac arrhythmias6.603.901.69
I84M1C1Haemorrhoids5.303.201.66
J00M1C1Acute nasopharyngitis [common cold]6.003.601.67
J02M1C1Acute pharyngitis15.509.401.65
J03M1C1Acute tonsillitis9.906.501.52
J04M1C1Acute laryngitis and tracheitis10.205.901.73
J11M1C1Influenza, virus not identified6.103.701.65
J22M1C2Unspecified acute lower respiratory infection4.502.601.73
J30M1C1Vasomotor and allergic rhinitis10.806.501.66
J31M1C1Chronic rhinitis, nasopharyngitis and pharyngitis5.002.901.72
J45M1C1Asthma8.405.401.56
K21M1C1Gastro-oesophageal reflux disease7.104.001.78
K29M1N/AGastritis and duodenitis3.601.802.00
K30M1C1Dyspepsia6.003.002.00
K58M1C1Irritable bowel syndrome4.802.501.92
K59M1N/AOther functional intestinal disorders3.601.901.89
L03M1C2Cellulitis4.602.701.70
R00M1N/AAbnormalities of heart beat3.301.801.83
R05M1C1Cough8.905.901.51
R06M1C1Abnormalities of breathing6.303.801.66
R07M1C1Pain in throat and chest11.206.501.72
R11M1N/ANausea and vomiting3.901.602.44
R42M1C4Dizziness and giddiness7.103.402.09
R50M1N/AFever of other and unknown origin4.902.701.81
R51M1C4Headache18.104.104.41
R52M1N/APain, not elsewhere classified3.201.701.88
R53M1C4Malaise and fatigue12.206.701.82
S13M1N/ADislocation, sprain and strain of joints and ligaments at neck level2.601.302.00
T78M1N/AAdverse effects, not elsewhere classified3.201.801.78
Z01M1C1Other special examinations and investigations of persons without complaint or reported diagnosis19.8014.101.40
Z03M1C1Medical observation and evaluation for suspected diseases and conditions6.203.601.72
Z71M1C1Persons encountering health services for other counselling and medical advice, not elsewhere classified15.6010.001.56
Z73M1N/AProblems related to life-management difficulty3.201.502.13
E78M2C2Disorders of lipoprotein metabolism and other lipidaemias4.403.201.38
G56M2C2Mononeuropathies of upper limb4.502.901.55
I10M2C2Essential (primary) hypertension11.308.701.30
J18M2N/APneumonia, organism unspecified3.202.501.28
M19M2N/AOther arthrosis2.501.801.39
M25M2C2Other joint disorders19.6012.801.53
M51M2C2Other intervertebral disc disorders6.704.101.63
M62M2N/AOther disorders of muscle3.501.801.94
M65M2C2Synovitis and tenosynovitis7.004.601.52
M67M2N/AOther disorders of synovium and tendon3.202.101.52
M70M2C2Soft tissue disorders related to use, overuse and pressure8.004.901.63
M72M2C2Fibroblastic disorders5.403.601.50
M75M2C2Shoulder lesions19.9013.301.50
M76M2C2Enthesopathies of lower limb, excluding foot4.703.101.52
M77M2C2Other enthesopathies15.309.901.55
N95M2C1Menopausal and other perimenopausal disorders7.905.201.52
S43M2N/ADislocation, sprain and strain of joints and ligaments of shoulder girdle3.402.101.62
Z10M2C1Routine general health check-up of defined subpopulation10.608.901.19
M17M3C2Gonarthrosis [arthrosis of knee]4.503.501.29
M23M3C2Internal derangement of knee7.104.801.48
S60M3C3Superficial injury of wrist and hand5.403.101.74
S61M3N/AOpen wound of wrist and hand4.002.901.38
S63M3C3Dislocation, sprain and strain of joints and ligaments at wrist and hand level5.203.401.53
S80M3C2Superficial injury of lower leg4.503.001.50
S83M3C2Dislocation, sprain and strain of joints and ligaments of knee6.204.501.38
S90M3N/ASuperficial injury of ankle and foot4.002.301.74
S93M3C2Dislocation, sprain and strain of joints and ligaments at ankle and foot level8.605.601.54
H60M4C1Otitis externa6.904.501.53
H65M4N/ANonsuppurative otitis media3.402.101.62
H66M4C1Suppurative and unspecified otitis media8.805.901.49
H92M4N/AOtalgia and effusion of ear3.101.801.72
D22M5C5Melanocytic naevi9.907.101.39
D23M5C5Other benign neoplasms of skin4.403.201.38
H52M5C1Disorders of refraction and accommodation6.904.001.73
H53M5N/AVisual disturbances4.201.403.00
L82M5C5Seborrhoeic keratosis3.902.601.50
R23M5N/AOther skin changes2.801.701.65
B35M6C6Dermatophytosis4.203.201.31
L02M6C2Cutaneous abscess, furuncle and carbuncle4.803.101.55
L08M6N/AOther local infections of skin and subcutaneous tissue3.002.001.50
L20M6C6Atopic dermatitis5.804.201.38
L30M6C6Other dermatitis8.906.501.37
L50M6N/AUrticaria3.502.301.52
R22M6C5Localized swelling, mass and lump of skin and subcutaneous tissue5.904.001.48
L70M7N/AAcne4.102.401.71
L71M7N/ARosacea3.001.601.88
H00M8N/AHordeolum and chalazion3.302.001.65
H01M8C6Other inflammation of eyelid4.102.501.64
N30M9C4Cystitis13.509.001.50
N39M9C4Other diseases of urinary system6.704.401.52
N64M9N/AOther disorders of breast2.501.601.56
N76M9C4Other inflammation of vagina and vulva5.703.901.46
N92M9C4Excessive, frequent and irregular menstruation9.206.901.33
N94M9N/APain and other conditions associated with female genital organs and menstrual cycle3.101.601.94
Z00M9C4General examination and investigation of persons without complaint and reported diagnosis8.605.301.62
Z30M9C4Contraceptive management6.405.101.25