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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Immunogenicity of biologic therapies for migraine: a review of current evidence

Fig. 1

Types of immunogenic responses. Immunogenic responses can lead to the formation of ADAs, which are further classified as NAbs or non-NAbs. ADAs that interact with 1 or more additional ADA can form large structures known as immune complexes. The immune complex in this figure depicts both NAb and non-NAb ADAs. ADA, anti-drug antibody; CGRP, calcitonin gene-related peptide; mAb, monoclonal antibody; NAb, neutralizing antibody; non-NAb, non-neutralizing antibody

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