Differential alteration of fMRI signal variability in the ascending trigeminal somatosensory and pain modulatory pathways in migraine

Lim, Manyoel; Jassar, Hassan; Kim, Dajung J.; Nascimento, Thiago D.; DaSilva, Alexandre F.

doi:10.1186/s10194-020-01210-6

Table 2 Brain regions with increased and decreased BOLD signal variability in migraine (EM + CM) patients compared with healthy controls

From: Differential alteration of fMRI signal variability in the ascending trigeminal somatosensory and pain modulatory pathways in migraine

Frequency band	Contrast	Brain region	Peak MNI coordinates			Number of voxels	T score
Frequency band	Contrast	Brain region	x	y	z	Number of voxels	T score
Overall low frequency (0.01–0.198 Hz)	Migraine > Controls	Left spinal trigeminal nucleus	−10	−38	−48	4	3.73*
		Right spinal trigeminal nucleus	8	−36	−52	7	3.93*
		Left thalamus	−12	−30	10	166	5.14
		Right thalamus	10	−22	−2	298	5.11
		Left dorsal posterior insula	−38	−24	16	114	5.01
		Left middle temporal gyrus	−48	−36	0	75	5.31
		Right hippocampus	22	−36	−2	69	4.87
		Left cerebellar vermis	−2	−48	−16	127	5.96
	Migraine < Controls	Right dorsolateral prefrontal cortex	44	22	36	75	5.41
	Migraine < Controls	Right inferior parietal cortex	38	−54	44	205	5.99
Slow-5 (0.01–0.027 Hz)	Migraine > Controls	Left thalamus	−12	−30	6	78	4.99
Slow-5 (0.01–0.027 Hz)	Migraine < Controls	Right inferior parietal cortex	38	−54	44	129	5.50
Slow-4 (0.027–0.073 Hz)	Migraine > Controls	Left thalamus	−12	−30	10	109	4.67
		Right thalamus	10	−22	−2	107	4.46
		Left dorsal posterior insula	−34	−22	16	123	4.53
		Left primary somatosensory cortex	−46	−30	60	56	4.46
	Migraine < Controls	Right dorsolateral prefrontal cortex	44	22	36	61	4.76
		Right inferior parietal cortex	40	−54	44	78	4.61
		Left angular gyrus	−50	− 62	20	58	4.19
Slow-3 (0.073–0.198 Hz)	Migraine > Controls	Left spinal trigeminal nucleus	−8	−36	−48	11	3.60*
		Right spinal trigeminal nucleus	8	−36	−52	16	3.86*
		Left thalamus	−14	−10	4	263	4.87
		Right thalamus	22	−24	12	146	5.80
		Right dorsal posterior insula	36	−24	22	58	4.86
		Left middle temporal gyrus	−48	−38	0	84	4.57
		Right hippocampus	26	−38	−8	125	5.34
		Left cerebellar vermis	−4	−48	−18	345	6.1
	Migraine < Controls	Right dorsolateral prefrontal cortex	44	24	40	88	5.31
		Right inferior parietal cortex	38	− 56	44	273	6.61
		Right angular gyrus	50	−60	16	86	5.26
		Left inferior parietal cortex	−40	−56	46	102	4.86

All statistical results were thresholded at voxel-level p < 0.001 and cluster-level p < .05, FWE-corrected. *p < .05, FWE-corrected using TFCE in the spinal trigeminal nucleus mask

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ISSN: 1129-2377

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