Fig. 4

Example of dynamic conditional correlation between the ventral posteromedial thalamic nucleus (VPM) and primary somatosensory cortex (S1), which have been filtered at 0.01–0.198 Hz (a) and group differences of dynamic functional connectivity (dFC) in the thalamocortical (b) and frontoparietal pathways (c). The strength and variability of dFC were derived by the mean and standard deviation of the DCC over time, respectively. Bar graphs of dFC strength and variability were expressed as mean ± SEM. Gray squares/bars represent MIG patients (n = 20) and white squares/bars represent HC subjects (n = 26). MIG patients were divided into EM (n = 13) or CM (n = 7) group for further subgroup comparison. ^*p < 0.05 and ^**p < 0.01 for unpaired t-test. L, left; R, right; dlPFC, dorsolateral prefrontal cortex; IPC, inferior parietal cortex; HC, healthy control; MIG, migraine; EM, episodic migraine; CM, chronic migraine