Fig. 8

The effect of MPEP on the expression of p-CREB-S133 and c-Fos. Compared with the sham group, the expression of p-CREB-S133 and c-Fos increased in the CM group. There were no significant differences between the CM and CM + DMSO groups. The administration of MPEP significantly downregulated their expression. a The protein expression of CREB. b The protein expression of p-CREB-S133. c The protein expression of c-Fos. d Immunoreactivity for c-Fos. (n = 4 in each group, scale bar = 20 μm; *p < 0.05 compared with the sham group; ^#p < 0.05 compared with the CM + DMSO group; N. S:p > 0.05 between two groups)