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Fig. 7 | The Journal of Headache and Pain

Fig. 7

From: Metabotropic glutamate receptor 5 regulates synaptic plasticity in a chronic migraine rat model through the PKC/NR2B signal

Fig. 7

The effect of MPEP on the expression of PKC and phosphorylation of NR2B at Tyr1472. Compared with the sham group, the expression of PKC and phosphorylation of NR2B at Tyr1472 increased in the CM group. There were no significant differences between the CM and CM + DMSO groups. The administration of MPEP significantly downregulated their expression. a The protein expression of PKC. b The protein expression of total NR2B. c The protein expression of phosphorylation of NR2B at Tyr1472. (n = 4 in each group; *p < 0.05 compared with the sham group; #p < 0.05 compared with the CM + DMSO group; N. S:p > 0.05 between two groups)

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