Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study

Table 2 The VBM and Reho comparisons between MwoA patients and healthy subjects

Contrast	Voxels	Brain regions	peak MNI (x, y, z)			Z score
*VBM comparison between MwoA patients and healthy subjects*
MwoA < HS	1508	bilateral superior and inferior colliculus / PAG / LC / MRN	-8	−23	−9	Inf
MwoA < HS	109	bilateral dorsal pons medulla junction	3	−38	−44	6.78
MwoA > HS	No brain region above the threshold.
*Reho comparison between MwoA patients and healthy subjects*
MwoA < HS	95	right MOG	33	−75	27	6.79
	12	right IOG	21	−72	36	5.14
	36	left MOG	−30	−81	21	6.14
MwoA > HS	11	bilateral MRN	6	−33	−24	4.93

HS healthy subjects, Inf infinity, IOG inferior occipital gyrus, LC locus ceruleus, MNI Montreal Neurological Institute coordinate, MOG middle occipital gyrus, MwoA migraine without aura patient, MRN median raphe nuclei, Reho regional homogeneity, VBM voxel-based morphometry
A threshold of P < 0.05 family wise error (FWE) correction at cluster level were applied for all comparisons. Z score infinity in this table means the probability of the VBM value in the peak MNI(x = − 8, y = −23, z = −9) of healthy subjects > migraineurs is approximately 100%

ISSN: 1129-2377