Fig. 4

In healthy individuals, a The relationship between mechanical punctate pain threshold at V1 and functional connectivity within pain-related regions. Significant correlations are noted at the delta to beta bands; b The relationship between mechanical punctate pain threshold at T1 and functional connectivity within pain-related regions. Significant correlations are observed at the alpha and beta bands. Each node presents the centroid of each region of interest. The lower part shows the correlation coefficients of the significant connectivity. MPPT, mechanical punctate pain threshold; ACC, anterior cingulate cortex; LOF, lateral orbitofrontal cortex; MOF, medial orbitofrontal cortex; SI, primary somatosensory cortex; PCC, posterior cingulate cortex; MI, primary motor cortex; V1, left supraorbital (the first branch of the trigeminal nerve dermatome)