Fig. 4From: Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspectsGPER receptor distribution in the Sp5 and Pontine nuclei. GPER was mainly found in the Pontine nuclei, cerebellar molecular layer and the spinal trigeminal tract. The spinal trigeminal tract region (Sp5) constitutes an essential part of the pain pathways activated in migraine attacks. We found GPER immunoreactive fibers in the Sp5 region. In Pontine nuclei the GPER immunoreactivity was mainly found in the cell nuclei, but some cytoplasmatic and fiber staining were also foundBack to article page