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Fig. 13 | The Journal of Headache and Pain

Fig. 13

From: Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects

Fig. 13

Myograph response to ERα and ERβ ligands on the human female dural vessel. Isolated segments of human female dural artery in the wire myograph. The data are shown as dilation from a preconstriction of U46619. To inhibit the endothelium L-NAME, indomethacin, apamin and charybdotoxin, where added. Cumulative concentration-response curves are shown for 17β-estrogen (a), PPT (b) or DPN (c). Data points represent means ± SEM. Significance was determined by two-way ANOVA, n = 6. *p < 0.05, **p < 0.005, *** p < 0.001

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