Fig. 11
From: Estrogen receptors α, β and GPER in the CNS and trigeminal system - molecular and functional aspects
Comparison of in situ CGRP and PACAP release from the dura and trigeminal ganglion. a The addition of 60 mM KCl (K+) caused no PACAP release from the dura but a significant release was seen from the TG in males (n = 12) but not in females (N = 10). CGRP release was much stronger both from the dura and the TG. b there were no significant differences in the CGRP releases in the dura or TG, however a significant lower baseline was observed in females in estrous. c Representative samples of the vaginal smears from the female rats, used to determine the cycle-stage. Data are shown as mean ± SEM or their individual data points with pairing, and with p values obtained with Student’s T-test being depicted in the graph. * = p < 0.05 between groups, and # = p < 0.05 from baseline