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Fig. 2 | The Journal of Headache and Pain

Fig. 2

From: Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine?

Fig. 2

Changes in CGRP plasma levels and miR-382-5p and miR-34a-5p expression in peripheral blood mononuclear cells of subjects with chronic migraine with medication overuse treated with a detoxification protocol. Study population: n = 28; 30% responders: n = 23; 30% non-responders: n = 5. PBMCs: peripheral blood mononuclear cells. Panel a: changes in CGRP plasma levels after detoxification. Panel b: changes in miR-382-5p expression in PBMCs after detoxification. Panel c: changes in miR-34-5p expression in PBMCs after detoxification. The box in the panels highlights the results of statistical analysis performed with two factors, non-parametric test for repeated measures: factor TIME: T0 vs. T1; factor GROUP: 30% responders vs. non-responders. Dashed lines represent estimates for each patient (red: 30% responders; black: 30% non-responders). Continuous lines represent the mean of the group (red: 30% responders; black: 30% non-responders). T0: baseline evaluation; T1: 2 months after discharge from in-hospital detoxification. RQ: Relative quantification: 2−∆∆Ct = 2 − (∆Ct gene − ∆Ct housekeeping gene); Ct: cycle threshold as defined in methods section

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