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Fig. 5 | The Journal of Headache and Pain

Fig. 5

From: Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with/without CGRP knock-down

Fig. 5

Electrophysiological findings for VPM thalamic output due to optogenetic stimulation of the motor cortex. a Evoked firing rates in VPM neurons in TN animals versus sham and control animals (***, p < 0.001, significant difference determined using unpaired t-tests). b, c In vivo recordings of the VPM thalamus from TN-Opto animals. b Findings for the TN-Opto-CGRP group. c Findings for the TN-Opto-PBS group. Decrease in firing output (spikes/s) were observed during the stimulation ON period. d, e No changes in firing rates of VPM thalamus were observed in the TN-Null-CGRP and TN-Null-PBS groups, respectively (two-way analysis of variance (ANOVA) *, p < 0.05; **, p < 0.01

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The Journal of Headache and Pain

ISSN: 1129-2377

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