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Fig. 4 | The Journal of Headache and Pain

Fig. 4

From: Optogenetic stimulation of the motor cortex alleviates neuropathic pain in rats of infraorbital nerve injury with/without CGRP knock-down

Fig. 4

Changes in behavioral responses following blue laser stimulation (a-c) along with knocking down of α-CGRP (d). Results for the air-puff test (a), cold hyperalgesia test (b), and von Frey test (c) for all eight animal groups. Only the TN-Opto-CGRP (a) and TN-Opto-PBS groups (b) exhibited significant changes in behavioral scores during the stimulation ON condition. No significant changes in behavior were observed in other animal groups during the stimulation ON condition. d Animals with α-CGRP injection exhibited more improvement in behavioral tests than animals with PBS injection. a Air puff force differences, b Cold hyperalgesia score differences and (c) Mechanical allodynia score differences between TN-Opto-CGRP and TN-Opto-PBS group. *, p < 0.05; **, p < 0.01, significant difference determined via an analysis of variance (ANOVA)

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The Journal of Headache and Pain

ISSN: 1129-2377

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