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Table 3 Hazard rate ratios of dementia associated with migraine diagnoses (N = 62,578)

From: Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study

Analysis Migraine diagnosis No. of individuals Minimum follow-up years between migraine and dementia Dementia cases/ person-years Model 1
HR (95% CI)
Model 2
HR (95% CI)
Main analysis None 51,721 ≥ 1 640/402,006 1.00 1.00
Any 10,857 ≥ 1 207/83,926 1.55 (1.32–1.81) 1.50 (1.28–1.76)
Migraine without aura 2845 ≥ 1 34/19,995 1.21 (0.85–1.72) 1.19 (0.84–1.70)
Migraine with aura 1698 ≥ 1 33/11,604 2.13 (1.50–3.03) 2.11 (1.48–3.00)
All other migraine types 6314 ≥ 1 140/52,328 1.55 (1.29–1.86) 1.48 (1.23–1.78)
Sensitivity analysis Any 10,773 ≥ 5 205/81,326 1.55 (1.32–1.81) 1.50 (1.28–1.76)
Any 10,198 ≥ 10 185/74,055 1.49 (1.26–1.75) 1.43 (1.21–1.69)
Any 9677 ≥ 15 174/69,486 1.53 (1.29–1.82) 1.48 (1.25–1.76)
Any 9271 ≥ 20 164/67,344 1.57 (1.32–1.87) 1.53 (1.28–1.83)
Additional refinement of exposure Number of contacts      
Migraine contactsa 0 40,718 ≥ 1 499/313,832 1.00 1.00
1 6233 ≥ 1 121/50,101 1.44 (1.18–1.76) 1.38 (1.13–1.69)
2 1428 ≥ 1 25/10,432 1.63 (1.09–2.43) 1.51 (1.01–2.27)
≥ 3 890 ≥ 1 6/5438 0.94 (0.42–2.11) 0.89 (0.40–2.00)
Hospital contactsb 0 51,721 ≥ 1 640/402,006 1.00 1.00
1 7836 ≥ 1 162/63,184 1.53 (1.29–1.82) 1.49 (1.25–1.77)
2 1810 ≥ 1 37/13,305 1.89 (1.36–2.64) 1.80 (1.29–2.51)
≥ 3 1211 ≥ 1 8/7437 0.92 (0.46–1.85) 0.89 (0.44–1.79)
  1. Model 1: adjusted for sex. Model 2: adjusted for sex, country of origin, marital status, educational level, headache diagnoses, psychiatric morbidities and Charlson Comorbidity Index (CCI)
  2. HR Hazard rate ratios, 95% CI 95% confidence intervals
  3. a Analyses of migraine contacts and dementia were based on individuals with any migraine diagnosis registered as the primary reason for hospital contact (N = 49,269)
  4. b Analyses of hospital contacts and dementia were based on individuals with any migraine diagnosis registered as either primary or secondary reason for hospital contact (N = 62,578)