Table 3 Hazard rate ratios of dementia associated with migraine diagnoses (N = 62,578)
From: Mid- to late-life migraine diagnoses and risk of dementia: a national register-based follow-up study
| Analysis | Migraine diagnosis | No. of individuals | Minimum follow-up years between migraine and dementia | Dementia cases/ person-years |
Model 1 HR (95% CI) |
Model 2 HR (95% CI) |
|---|---|---|---|---|---|---|
| Main analysis | None | 51,721 | ≥ 1 | 640/402,006 | 1.00 | 1.00 |
| Any | 10,857 | ≥ 1 | 207/83,926 | 1.55 (1.32–1.81) | 1.50 (1.28–1.76) | |
| Migraine without aura | 2845 | ≥ 1 | 34/19,995 | 1.21 (0.85–1.72) | 1.19 (0.84–1.70) | |
| Migraine with aura | 1698 | ≥ 1 | 33/11,604 | 2.13 (1.50–3.03) | 2.11 (1.48–3.00) | |
| All other migraine types | 6314 | ≥ 1 | 140/52,328 | 1.55 (1.29–1.86) | 1.48 (1.23–1.78) | |
| Sensitivity analysis | Any | 10,773 | ≥ 5 | 205/81,326 | 1.55 (1.32–1.81) | 1.50 (1.28–1.76) |
| Any | 10,198 | ≥ 10 | 185/74,055 | 1.49 (1.26–1.75) | 1.43 (1.21–1.69) | |
| Any | 9677 | ≥ 15 | 174/69,486 | 1.53 (1.29–1.82) | 1.48 (1.25–1.76) | |
| Any | 9271 | ≥ 20 | 164/67,344 | 1.57 (1.32–1.87) | 1.53 (1.28–1.83) | |
| Additional refinement of exposure | Number of contacts | |||||
| Migraine contactsa | 0 | 40,718 | ≥ 1 | 499/313,832 | 1.00 | 1.00 |
| 1 | 6233 | ≥ 1 | 121/50,101 | 1.44 (1.18–1.76) | 1.38 (1.13–1.69) | |
| 2 | 1428 | ≥ 1 | 25/10,432 | 1.63 (1.09–2.43) | 1.51 (1.01–2.27) | |
| ≥ 3 | 890 | ≥ 1 | 6/5438 | 0.94 (0.42–2.11) | 0.89 (0.40–2.00) | |
| Hospital contactsb | 0 | 51,721 | ≥ 1 | 640/402,006 | 1.00 | 1.00 |
| 1 | 7836 | ≥ 1 | 162/63,184 | 1.53 (1.29–1.82) | 1.49 (1.25–1.77) | |
| 2 | 1810 | ≥ 1 | 37/13,305 | 1.89 (1.36–2.64) | 1.80 (1.29–2.51) | |
| ≥ 3 | 1211 | ≥ 1 | 8/7437 | 0.92 (0.46–1.85) | 0.89 (0.44–1.79) |
