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Table 4 Median values of laboratory parameters in the whole sample and the comparison between patients with and without headache

From: Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study

Variable All patients
(n = 576)
Headache
(n = 137)
No headache
(n = 439)
p-value
Leukocytes at admission 6710 (4945–8885.00) 6290.00 (4682.50–8257.50) 6785.00 (5137.50–9302.50) 0.202
Worst leukocyte count 9425.00 (4442.50–14,182.50) 6245.00 (3875.00–11,422.50) 9975.00 (4722.50–14,625.00) < 0.001
Lymphocytes at admission 990.00 (710.00–1387.50) 1117.00 (850.00–1495.00) 940.00 (680.00–1350.00) 0.003
Worst lymphocyte count 690.00 (430.00–1050.00) 910.00 (575.00–1220.00) 650.00 (410.00–990.00) 0.001
Platelets at admission 195,000.00 (156,000.00–257,000.00) 197,500.00 (170,500.00–240,750.00) 194,000.00 (149,000.00–264,000.00) 0.677
Worst platelet count 192,500.00 (137,000.00–341,250.00) 206,000.00 (163,000.00–384,500.00) 188,000.00 (134,000.00–333,500.00) 0.111
LDH at admission 285.00 (225.00–372.00) 263.00 (215.00–341.00) 292.50 (227.00–381.50) 0.019
Worst LDH value 285.00 (225.00–372.00) 301.50 (237.00–411.75) 365.00 (268.50–487.00) < 0.001
CK at admission 83.00 (49.00–372.00) 72.00 (49.5–110) 86.00 (47.00–166.00) 0.605
Worst CK value 89.00 (53.25–179.75) 79.00 (49.00–136.00) 94.00 (55.50–192.00) 0.026
CRP at admission 65.90 (23.37–122.15) 40.55 (14.15–102.26) 73.40 (28.55–130.05) 0.002
Worst CRP value 105.00 (51.25–198.02) 67.90 (21.70–164.40) 113.40 (58.45–208.62) < 0.001
PCT at admission 0.10 (0.06–0.26) 0.07 (0.04–0.14) 0.11 (0.07–0.30) 0.001
Worst PCT value 0.13 (0.06–0.43) 0.07 (0.04–0.18) 0.15 (0.08–0.54) < 0.001
Worst ferritin value 979.00 (444.40–1819.00) 615.00 (306.80–1449.70) 1094.80 (534.75–1945.47) < 0.001
Worst IL-6 value 27.80 (12.40–61.87) 17.95 (9.76–44.15) 33.50 (13.32–67.30) 0.001
D-Dimer at admission 761.50 (462.75–1369.00) 550.00 (380–864) 855.50 (515–50-1570.00) 0.001
Worst D-Dimer value 1300.00 (674.75–3231.75) 810.00 (504.50 (1458.50) 1534.00 (795.00–3580.00) < 0.001
INR at admission 1.18 (1.10–1.29) 1.15 (1.08–1.23) 1.19 (1.11–1.32) 0.003
Worst INR value 1.25 (1.15–1.40) 1.19 (1.11–1.30) 1.26 (1.17–1.45) < 0.001
  1. LDH Lactate dehydrogenase, CK Creatine Kinase, CRP C-reactive protein, PCT Procalcitonin, IL-6 interleukin 6, INR International normalized ratio. In bold, variables that were statistically significant after adjusting for multiple comparisons (threshold p < 0.0025)
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