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Table 4 Phases of prescribed preventive medications for patients with migraine who received at least one prescription for the respective in- and off-label (Group 2) preventive medication in the German Company Sickness Fund Database 2008 to 2016

From: Administrative prevalence and incidence, characteristics and prescription patterns of patients with migraine in Germany: a retrospective claims data analysis

Preventive medication Mean number of phases
(per person-year)a
Mean duration of phases (days per person-year)b
All 1.15 119.1
Valproic acid 1.51 131.1
Candesartan 1.48 306.3
Bisoprolol 1.45 117.6
Onabotulinum toxin Ac 1.41 278.5
Topiramate 1.25 138.3
Metoprolol 1.22 103.5
ARAs (‘sartans’) 1.20 274.4
Amitriptyline 1.16 92.4
Propranolol 1.11 70.1
Opipramol 1.05 81.1
Flunarizine 0.84 92.6
Lisinopril 0.67 137.5
  1. Data shown are for prescribed Group 2 preventive medications (all preventive medications according to the German guideline for migraine [8])
  2. aCalculated as the number of phases (continuous prescriptions) divided by the amount of person-time at risk (first prescription to end of enrolment)
  3. bCalculated as the number of days covered by continuous prescriptions divided by the amount of person-time at risk (first prescription to end of enrolment)
  4. cPrescriptions for the Allergan brand of onabotulinum toxin A only were included
  5. ARA angiotensin II receptor antagonist
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