Fig. 6

Percentage of patients with no, at least one, or at least two prescriptions of preventive medications from different classes in the German Company Sickness Fund Database 2008 to 2016. Preventive medications considered were Group 1 (in-label preventive medications plus valproic acid, i.e. [metoprolol or propranolol], amitriptyline, flunarizine, topiramate, onabotulinum toxin A or valproic acid) and Group 2 (preventive medications according to German guideline for migraine [10]: Group 1 preventive medications plus opipramol, lisinopril or angiotensin II receptor antagonist [‘sartan’] therapy); magnesium was excluded from these analyses because no defined daily dose was available