Fig. 6

Knockdown of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion ameliorated hyperalgesia and vestibular dysfunction after CM. a Basal and post-treatment responses (b) of hindpaw thermal hyperalgesia were significantly decreased with pretreatment of LV-VGRP. (c) Head grooming time was significantly decreased in LV-CGRP-treated rats compared with LV-NC-treated group. Balance beam walk (d), geotaxis reflex (e) and vestibular dysfunction scores (f) showing that pretreatment of LV-CGRP restored impairments in dynamic and static postural control compared with the LV-NC group. n = 8/group. Data are mean ± SEM. Analysis of variance (ANOVA), Tukey; *p < 0.05 compared with vehicle, #p < 0.05 compared with before NTG injection