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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine

Fig. 3

Upregulation of c-fos and calcitonin gene-related peptide (CGRP) in the trigeminal nucleus caudalis (TNC) and vestibular nuclei (VN) after CM. a Representative images of c-fos (red)-positive staining in the TNC and VN post CM. b Quantification of c-fos + cells in right and left sides of TNC and VN, showing significantly increased number of c-fos + cells after CM compared with vehicle group. FOV = 1.02 × 106 μm3. c Representative images of CGRP (green)-positive staining in the TNC (upper panel) and VN (middle and lower panel) after CM. Data showed that CM group had greater CGRP signals (d) in the TNC compared with vehicle group. e qRT-PCR results showed that the mRNA level of endogenous CGRP significantly increased after CM. a (c: upper and lower panel) Scale bar = 50 μm, (c: middle panel) Scale bar = 100 μm; *P < 0.05 compared with vehicle, n = 8/group. Data are mean ± SEM. Student’s t-test. V: ventricle

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