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Table 2 Risk of migraine in HUNT4 based on categories of high sensitivity C-reactive protein (hs-CRP) in HUNT3 evaluated by poisson regression with 95% confidence interval

From: High sensitivity C-reactive protein and risk of migraine in a 11-year follow-up with data from the Nord-Trøndelag health surveys 2006–2008 and 2017–2019

Hs-CRP (mg/L)

Number

Migraine (overall)

Migraine with aura

Migraine without aura

Episodic migraine

Chronic migraine

RR (95% CI)

RR (95% CI)

RR (95% CI)

RR (95% CI)

RR (95% CI)

Model 1 (Adjusted for age and gender)

 < 3.0

15,841

1.00

1.00

1.00

1.00

1.00

 3.00–9.99

3253

1.03 (0.86–1.24)

1.00 (0.76–1.33)

1.06 (0.82–1.36)

1.05 (0.87–1.28)

0.76 (0.35–1.66)

 10.00–20.00

480

1.53 (1.10–2.14)

1.67 (1.01–2.76)

1.50 (0.93–2.42)

1.41 (0.98–2.04)

3.43 (1.38–8.52)

Model 2 (Adjusted for age, gender and body mass index)

 ≤ 2.99

15,841

1.00

1.00

1.00

1.00

1.00

 3.00–9.99

3253

0.98 (0.81–1.18)

0.96 (0.72–1.29)

1.00 (0.77–1.29)

1.00 (0.82–1.22)

0.71 (0.33–1.54)

 10.00–20.00

480

1.44 (1.03–2.03)

1.60 (0.95–2.66)

1.38 (0.86–2.24)

1.32 (0.91–1.92)

3.36 (1.29–8.28)

Model 3 (Multi-adjusted modela)

 ≤ 2.99

15,841

1.00

1.00

1.00

1.00

1.00

 3.00–9.99

3253

1.00 (0.74–1.35)

0.96 (0.73–1.27)

1.02 (0.80–1.30)

1.01 (0.84–1.21)

0.71 (0.32–1.56)

 10.00–20.00

480

1.46 (1.05–2.04)

1.57 (0.95–2.59)

1.44 (0.90–2.32)

1.35 (0.94–1.94)

2.81 (1.12–7.06)

  1. aMulti-adjusted model: Adjusted for age, sex, body mass index, smoking, education level, alcohol use, headache status and Hospital Anxiety and Depression Scale score