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Table 2 Risk of migraine in HUNT4 based on categories of high sensitivity C-reactive protein (hs-CRP) in HUNT3 evaluated by poisson regression with 95% confidence interval

From: High sensitivity C-reactive protein and risk of migraine in a 11-year follow-up with data from the Nord-Trøndelag health surveys 2006–2008 and 2017–2019

Hs-CRP (mg/L)NumberMigraine (overall)Migraine with auraMigraine without auraEpisodic migraineChronic migraine
RR (95% CI)RR (95% CI)RR (95% CI)RR (95% CI)RR (95% CI)
Model 1 (Adjusted for age and gender)
 < 3.015,8411.001.001.001.001.00
 3.00–9.9932531.03 (0.86–1.24)1.00 (0.76–1.33)1.06 (0.82–1.36)1.05 (0.87–1.28)0.76 (0.35–1.66)
 10.00–20.004801.53 (1.10–2.14)1.67 (1.01–2.76)1.50 (0.93–2.42)1.41 (0.98–2.04)3.43 (1.38–8.52)
Model 2 (Adjusted for age, gender and body mass index)
 ≤ 2.9915,8411.001.001.001.001.00
 3.00–9.9932530.98 (0.81–1.18)0.96 (0.72–1.29)1.00 (0.77–1.29)1.00 (0.82–1.22)0.71 (0.33–1.54)
 10.00–20.004801.44 (1.03–2.03)1.60 (0.95–2.66)1.38 (0.86–2.24)1.32 (0.91–1.92)3.36 (1.29–8.28)
Model 3 (Multi-adjusted modela)
 ≤ 2.9915,8411.001.001.001.001.00
 3.00–9.9932531.00 (0.74–1.35)0.96 (0.73–1.27)1.02 (0.80–1.30)1.01 (0.84–1.21)0.71 (0.32–1.56)
 10.00–20.004801.46 (1.05–2.04)1.57 (0.95–2.59)1.44 (0.90–2.32)1.35 (0.94–1.94)2.81 (1.12–7.06)
  1. aMulti-adjusted model: Adjusted for age, sex, body mass index, smoking, education level, alcohol use, headache status and Hospital Anxiety and Depression Scale score
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