Skip to main content

Table 2 Pros and cons of animal models

From: Persistent post-traumatic headache: a migrainous loop or not? The preclinical evidence

Advantages Disadvantages
- Precise control of physical parameters during trauma - Differences in gross anatomy as compared to humans (e.g. lack of gyri/sulci)
- Trauma can be ‘dissected’ to focus on particular physical mechanisms, for example, rotational acceleration - Differences in the physiology and timewise progression of pathology as compared to humans
- Possibility to control age and genetics (including sex) - Few models for concussion available
- Possibility to monitor post-traumatically development of pathologies with exact timetables for evaluation and possibility to include baseline data - Difficult to translate outcome parameters for concussion between rodents and humans