Table 2 Brain regions with decreased functional connectivity (FC) in migraine without aura (MWoA) compared to healthy controls (HC)
Predominant regions in the cluster | Cluster size | Peak T | MNI coordinates | pFWE − corr | ||
|---|---|---|---|---|---|---|
(number of voxels) | Â | x | y | z | Â | |
Seed in L M1 | ||||||
 Right middle occipital gyrus | 199 | −5.28 | 36 | −69 | 3 | 0.000 |
 Right middle temporal gyrus | 151 | −5.19 | 57 | −57 | 0 | 0.000 |
 Right superior temporal gyrus | 177 | −4.85 | 63 | −27 | 15 | 0.000 |
 Parietal_Sup_L (aal) | 303 | −4.73 | −30 | − 48 | 57 | 0.000 |
 Right postcentral gyrus | 342 | −4.51 | 30 | −45 | 66 | 0.000 |
 Right middle frontal gyrus | 135 | −4.44 | 36 | −3 | 48 | 0.001 |
Seed in R M1 | ||||||
 Right middle occipital gyrus | 122 | −5.00 | 36 | −69 | 6 | 0.002 |
 Right superior temporal gyrus | 60 | −4.59 | 63 | −27 | 15 | 0.046 |
 Parietal_Sup_L (aal) | 307 | −4.57 | − 30 | − 45 | 57 | 0.000 |
 Postcentral_R (aal) | 164 | −4.24 | 33 | −42 | 57 | 0.000 |
 Right cuneus | 64 | −3.97 | 21 | −93 | 18 | 0.036 |
Seed in L S1 | ||||||
 Precuneus_L (aal) extending to | 176 (971) | −5.73 | −9 | −48 | 69 | 0.000 |
 Bilateral postcentral gyrus | 229 (971) |  |  |  |  |  |
 Bilateral Paracentral lobule | 210 (971) |  |  |  |  |  |
 Precuneus_R (aal) | 112 (971) |  |  |  |  |  |
 Right middle temporal gyrus | 144 | −5.25 | 57 | −54 | 0 | 0.001 |
 Right superior temporal gyrus | 195 | −4.96 | 63 | −30 | 15 | 0.000 |
 Left inferior parietal lobule | 157 | −4.84 | −57 | −39 | 21 | 0.000 |
 Left middle temporal gyrus | 108 | −4.58 | −45 | −66 | 12 | 0.004 |
 Right inferior frontal gyrus | 61 | −4.54 | 48 | 33 | 9 | 0.047 |
 Postcentral_L (aal) | 76 | −4.22 | −21 | −30 | 66 | 0.020 |
 Right middle frontal gyrus | 112 | −4.22 | 45 | 0 | 45 | 0.003 |
Seed in R S1 | ||||||
 Precuneus_R (aal) extending to | 166 (1219) | −5.13 | 12 | −42 | 63 | 0.000 |
 Precuneus_L (aal) | 98 (1219) |  |  |  |  |  |
 Right cingulate gyrus | 67 (1219) |  |  |  |  |  |
 Bilateral postcentral gyrus | 320 (1219) |  |  |  |  |  |
 Bilateral paracentral lobule | 252(1219) |  |  |  |  |  |
 Bilateral precentral gyrus | 246(1219) |  |  |  |  |  |
 Right superior temporal gyrus | 86 | −4.78 | 63 | −30 | 15 | 0.011 |
 Left inferior parietal lobe | 61 | −4.59 | − 60 | − 42 | 21 | 0.046 |
 Occipital_Sup_L (aal) | 87 | −4.13 | −21 | −60 | 18 | 0.010 |
Seed in L SMA | ||||||
 Precentral_L (aal) extending to | 95 (665) | −5.62 | −51 | 0 | 42 | 0.000 |
 Left precuneus | 112 (665) |  |  |  |  |  |
 Parietal_Inf_L (aal) | 210 (665) |  |  |  |  |  |
 Postcentral_L (aal) | 198 (665) |  |  |  |  |  |
 Right middle frontal gyrus extending to | 131 (852) | −5.55 | 36 | −6 | 51 | 0.000 |
 Right inferior parietal lobule | 145 (852) |  |  |  |  |  |
 Postcentral_R (aal) | 274 (852) |  |  |  |  |  |
 Precentral_R (aal) | 177 (852) |  |  |  |  |  |
 Right cuneus | 217 (605) | −5.22 | 15 | −78 | 30 | 0.000 |
 Left middle temporal gyrus | 77 (605) |  |  |  |  |  |
 Right superior temporal gyrus | 76 | −4.95 | 63 | −27 | 15 | 0.020 |
 Right middle temporal gyrus | 267 | −4.72 | 60 | −54 | 6 | 0.000 |
Seed in R SMA | ||||||
 Right middle frontal gyrus extending to | 104 (1942) | −5.57 | 39 | −6 | 51 | 0.000 |
 Bilateral postcentral gyrus | 373 (1942) |  |  |  |  |  |
 Bilateral precentral Gyrus | 330 (1942) |  |  |  |  |  |
 Bilateral inferior parietal lobule | 243 (1942) |  |  |  |  |  |
 Bilateral cuneus | 232 (1942) |  |  |  |  |  |
 Bilateral precuneus | 221 (1942) |  |  |  |  |  |
 Right middle temporal gyrus | 91 | −4.28 | 57 | −54 | −6 | 0.009 |
Seed in R preSMA | ||||||
 Left precuneus | 110 | 4.05 | −18 | −72 | 39 | 0.004 |
Seed in R PMd | ||||||
 Left precuneus | 306 | −4.88 | −18 | −57 | 54 | 0.000 |
 Left middle occipital gyrus | 200 | −4.75 | −36 | −78 | 9 | 0.000 |
 Cerebellum_8_R | 83 | −4.49 | 18 | −60 | −57 | 0.013 |
 Right cuneus | 144 | −4.47 | 21 | −93 | 18 | 0.001 |
 Right middle occipital gyrus | 103 | −4.11 | 36 | −81 | 0 | 0.005 |
 Right postcentral gyrus | 101 | −4.11 | 9 | −45 | 66 | 0.005 |
 Left cuneus | 68 | −3.84 | − 18 | − 87 | 18 | 0.031 |
Seed in L PMv | ||||||
 Left precentral gyrus | 107 | −4.50 | −27 | −30 | 57 | 0.004 |
 Right cingulate gyrus | 111 | −3.92 | −9 | −9 | 39 | 0.003 |
 Right postcentral gyrus | 75 | −3.77 | 12 | −45 | 69 | 0.022 |
Seed in R PMv | ||||||
 Bilateral precuneus extending to | 139 (469) | −4.75 | 12 | −45 | 63 | 0.000 |
 Bilateral postcentral gyrus | 173 (469) |  |  |  |  |  |
 Supp_Motor_Area_L (aal) | 109 | −4.32 | 0 | −18 | 51 | 0.004 |