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Table 3 Migraine treatment characteristics

From: A global real-world assessment of the impact on health-related quality of life and work productivity of migraine in patients with insufficient versus good response to triptan medication

Treatment, n (%) TIRs
(n = 483)
TRs
(n = 930)
All
(n = 1413)
p-valuea
Triptan prescribedb,c
 Sumatriptan 194 (40.2) 435 (46.8) 629 (44.5) 0.018
 Sumatriptan + naproxen 24 (5.0) 55 (5.9) 79 (5.6) 0.463
 Rizatriptan 85 (17.6) 157 (16.9) 242 (17.1) 0.734
 Zolmitriptan 82 (17.0) 147 (15.8) 229 (16.2) 0.571
 Almotriptan 19 (3.9) 57 (6.1) 76 (5.4) 0.083
 Eletriptan 33 (6.8) 42 (4.5) 75 (5.3) 0.065
 Naratriptan 34 (7.0) 27 (2.9) 61 (4.3) < 0.001
 Frovatriptan 18 (3.7) 11 (1.2) 29 (2.1) 0.001
No. of unique triptans ever used, n (%)b     < 0.001
 1 389 (80.5) 824 (88.6) 1213 (85.8)  
 2 80 (16.6) 98 (10.5) 178 (12.6)  
 3+ 14 (2.9) 8 (0.9) 22 (1.6)  
Timing of acute medication used     < 0.001
 At the first sign of a migraine attack (premonitory phase; before pain starts) 276 (58.2) 641 (70.5) 917 (66.3)  
 When the pain starts 162 (34.2) 238 (26.2) 400 (28.9)  
 After the pain has started and severity is known 36 (7.6) 30 (3.3) 66 (4.8)  
Current use of OTC migraine medicationd 100 (21.8) 140 (15.6) 240 (17.7) 0.005
Mean amount spent in last month on OTC products, $ (SD)e 12.78 (17.55) 10.54 (9.34) 11.42 (13.21) 0.294
Reason for OTC used
 Prescribed medication not effective enough 47 (50.5) 37 (29.1) 84 (38.2) 0.001
 My doctor recommended it 22 (23.7) 47 (37.0) 69 (31.4) 0.035
 I run out of my prescribed medication 20 (21.5) 14 (11.0) 34 (15.5) 0.034
 Prescribed medication is too expensive 9 (9.7) 11 (8.7) 20 (9.1) 0.796
Current use of preventive medicationb 262 (54.2) 390 (41.9) 652 (46.1) < 0.001
 Anticonvulsants 102 (21.1) 106 (11.4) 208 (14.7) < 0.001
 Antidepressants/anxiolytics/benzodiazepines 48 (9.9) 70 (7.5) 118 (8.4) 0.120
 Antimigraine 8 (1.7) 8 (0.9) 16 (1.1) 0.180
 Beta blockers 89 (18.4) 159 (17.1) 248 (17.6) 0.533
 Calcium antagonists 14 (2.9) 36 (3.9) 50 (3.5) 0.348
 NSAIDS, including combinations 4 (0.8) 7 (0.8) 11 (0.8) 1.000
 Others 16 (3.3) 19 (2.0) 35 (2.5) 0.145
History of opioid misuse, n (%)b 19 (3.9) 20 (2.2) 39 (2.8) 0.019
  1. aP-values from test of two group difference: t-test for continuous variables and chi-square for categorical variables. bPhysician reported. cPatients could be receiving more than one triptan, but no other acute medication type. dPatient reported. eAverage currency exchange rate at year 2017 was used to convert to US dollar amounts. Website referred to: https://www.irs.gov/individuals/international-taxpayers/yearly-average-currency-exchange rates
  2. NSAID nonsteroidal anti-inflammatory drug; OTC over-the-counter; TIR triptan insufficient responder; TR triptan responder