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Table 1 Concentration levels of the measured metabolites in the analyzed brain regions

From: Neurotransmitter and tryptophan metabolite concentration changes in the complete Freund’s adjuvant model of orofacial pain

 

Control group (n = 9)

CFA 24 h (n = 9)

CFA 48 h (n = 8)

Trigeminal nucleus caudalis (TNC)

 Glu (μg/g ww)

684 (644–746)

772*,# (742–859)

731 (687–745)

 GABA (μg/g ww)

167 (154–187)

180 (174–235)

167 (164–171)

 TRP (nmol/g ww)

20.3 (19.2–22.4)

20.3 (18.2–24.5)

19.4 (17.7–20.8)

 KYN (nmol/g ww)

0.656 (0.428–0.671)

0.876*,# (0.830–1.13)

0.532 (0.480–0.597)

 KYNA (pmol/g ww)

22.8 (21.2–24.2)

52.6**,# (34.6–72.3)

25.8 (21.9–28.8)

 5-HT (pmol/g ww)

2991 (2917–3333)

2841 (2629–3425)

3315 (3088–3438)

 NA (μg/g ww)

0.328 (0.320–0.343)

0.352 (0.328–0.388)

0.348 (0.324–0.366)

Somatosensory cortex (ssCX)

 Glu (μg/g ww)

1178 (1082–1290)

1269 (1206–1397)

1152 (1052–1287)

 GABA (μg/g ww)

215 (207–218)

230 (217–251)

199 (178–211)

 TRP (nmol/g ww)

20.6 (17.8–23.5)

22.6 (21.5–23.7)

21.6 (20.9–22.7)

 KYN (nmol/g ww)

0.824 (0.743–0.970)

0.974 (0.714–1.15)

0.616 (0.552–0.663)

 KYNA (pmol/g ww)

16.2 (9.70–18.8)

27.3*,# (17.3–39.3)

9.73 (7.01–12.8)

 5-HT (pmol/g ww)

2547 (1665–2677)

2271# (2166–2527)

2885 (2653–3172)

 NA (μg/g ww)

0.840 (0.192–0.853)

0.754 (0.142–0.934)

0.886 (0.556–0.974)

  1. Results are shown as median (1st-3rd quartile). One animal died in cage after CFA injection. * p < 0.05 vs. CO, ** p < 0.01 vs. CO, # p < 0.05 vs. 48 h, 5-HT serotonin, CFA Complete Freund’s adjuvant, GABA gamma-aminobutyric acid, Glu glutamate, KYN kynurenine, KYNA kynurenic acid, n number of the animals per group, NA noradrenaline, TRP tryptophan, ww wet weight