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Table 1 Demographics, clinical profiles, and neuroimaging data of patients with HFM and HC

From: The cerebellum is associated with 2-year prognosis in patients with high-frequency migraine

 

HC

(n = 37)

HFM

(n = 56)

HFM

Good outcome (n = 37)

HFM

Poor outcome (n = 19)

Age

39.4 ± 9.3

40.3 ± 10.5

40.8 ± 11.1

39.4 ± 9.6

Sex (F/M)

27/10

43/13

27/10

16/3

Aura (%)

nil

9 (16%)

7 (18.9%)

2 (10.5%)

Headache frequency-baseline (d/m)

nil

19.2 ± 7.1

18.9 ± 7.1

19.7 ± 7.4

Chronic migraine

nil

44 (78.6%)

29 (78.4%)

15 (78.9%)

Disease duration (years)

nil

17.2 ± 11.3

15.7 ± 10.2

20.1 ± 13.0

Headache intensity (NRS 0–10)

nil

6.5 ± 1.7

6.6 ± 1.7

6.3 ± 2.0

MIDAS

nil

43.9 ± 49.0

20 ± 50

62.5 ± 92

HADS-A

4.7 ± 2.5#

8.9 ± 4.3

9.1 ± 4.3

8.5 ± 4.3

HADS-D

3.5 ± 2.8#

6.8 ± 5.0

6.7 ± 5.5

6.8 ± 4.2

Prophylactic drugs use

nil

48 (85.7%)

30 (81.1%)

18 (94.7%)

Prophylactic drugs use at 2-year follow-up

nil

16 (28.6%)

10 (27%)

6 (31.6%)

Headache frequency at 2-year follow-up (d/m)

nil

9.0 ± 9.5

3.3 ± 2.4*

20.3 ± 7.8

TIV (mm3)

1430.8 ± 129.6

1399.8 ± 132.5

1404.7 ± 124.6

1390.2 ± 149.7

  1. HC healthy controls, HFM high frequency migraine, NRS numeric rating scale, MIDAS Migraine Disability Assessment, HADS-A the anxiety subscale of the Hospital Anxiety and Depression Scale, HADS-D the depression subscale of the Hospital Anxiety and Depression Scale, TIV total intracranial volume
  2. # denotes difference comparing patients with HFM to HC, p < 0.05
  3. *denotes difference comparing patients with HFM with good to poor outcomes, p < 0.05