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Table 1 (abstract A.57). Change from baseline in monthly average migraine days during 12-weeks of double-blind treatment by sex and age groupa

From: 13th European Headache Federation Congress 2019: Meeting Abstracts - part 2

 

Placebo

Monthly fremanezumab

Quarterly fremanezumab

Males

(n = 46)

(n = 45)

(n = 47)

 LSM (SE) change

−0.4 (0.74)

−4.6 (0.78)

−4.2 (0.73)

 LSMD (SE) vs placebo

–

−4.2 (0.91)b

− 3.8 (0.87)b

Females

(n = 232)

(n = 238)

(n = 229)

 LSM (SE) change

−0.6 (0.35)

−3.9 (0.34)

−3.6 (0.35)

 LSMD (SE) vs placebo

–

−3.3 (0.39)b

− 3.0 (0.39)b

Age 18–45 years

(n = 120)

(n = 128)

(n = 125)

 LSM (SE) change

−0.8 (0.47)

−4.6 (0.49)

−4.1 (0.48)

 LSMD (SE) vs placebo

–

−3.8 (0.51)b

− 3.2 (0.51)b

Age > 45 years

(n = 158)

(n = 155)

(n = 151)

 LSM (SE) change

−0.4 (0.48)

−3.8 (0.47)

−3.6 (0.49)

 LSMD (SE) vs placebo

–

−3.4 (0.50)b

− 3.2 (0.51)b

  1. LSM least-squares mean, LSMD LSM difference
  2. aModified ITT population (n = 837)
  3. bP < 0.0001 vs placebo