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Table 2 Changes in migraine characteristics, the use of analgesics and serum CGRP levels before and after supplementation with vitamin D or placebo in episodic migraine patients

From: The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial

 Vitamin D Group (n = 38)Placebo Group (n = 36)P value for baseline comparisonP value for end of trial comparison
BaselineAfter 12 WeeksBaselineAfter 12 Weeks
Serum 25OHD Levels (ng/ml)
 Mean (SD)27.31 (12.30)39.65 (13.45)33.70 (11.08)33.95 (12.14)0.0170.062£
 Changes from baseline12.34 (6.34)−0.28 (5.90)  
P value for within-group comparison< 0.001#0.782#  
Number of Headache Days per month
 Mean (SD)8.04 (3.35)5.07 (2. 82)7.69 (3.39)7.26 (3. 86)0.6440.006£
 Adjusted mean (95%CI) 4.71 (3.64–5.77) 6.43 (5.28–7.58) 0.031 δ
 Changes from baseline−2.90 (3.03)- 0.14 (2.91) 
P value for within-group comparison< 0.001#0.776#  
Migraine Related Disability (MIDAS score)
 29.75 (18. 54)19.38 (16. 43)36.87 (21. 55)35.36 (19. 45)0.117< 0.001£
 Adjusted mean (95%CI) 21.49 (16.22–26.77) 31.16 (25.51–36.82) 0.016 δ
 Changes from baseline−10.38 (12.29)0.33 (14. 82) 
P value for within-group comparison< 0.001#0.893#  
Serum CGRP levels (ng/L)
 Mean (SD)195.27 (78.45)167.961 (80.112)166.05 (58.32)176.71 (72.22)0.0630.626£
 Adjusted mean (95%CI) 153.26 (133.03–173.49) 188.35 (167.15–209.54) 0.022
 Changes from baseline−27.31 (59.69)12.57 (23.85) 
P value for within-group comparison0.006#0.004#  
  1. P value < 0.05 was considered significant
  2. The second row of this table was previously published in [24] in a slightly different format
  3. BMI Body mass index, MIDAS Migraine disability assessment questionnaire, CGRP Calcitonin gene-related peptide
  4. #Paired sample t-test
  5. £ Independent t-test
  6. δANCOVA test adjusted for baseline values, age, sex, and BMI change
  7. ANCOVA test adjusted for baseline CGRP levels, age, sex, BMI change, the years having headache, and time from last attack
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