|  | MIDAS total < 21 at baseline | MIDAS total ≥ 21 at baseline | ||||||
---|---|---|---|---|---|---|---|---|---|
Lasmiditan 100 mg (n = 418) | Lasmiditan 200 mg (n = 465) | Lasmiditan 100 mg (n = 554) | Lasmiditan 200 mg(n = 598) | ||||||
 | LS mean | % change in mean | LS mean | % change in mean | LS mean | % change in mean | LS mean | % change in mean | |
MIDAS Total | Baseline, mean | 13.8 | 13.8 | 41.1 | 40.7 | ||||
Month 3 | −0.6 | −4.2 | −1.7** | −12.5 | −13.3** | −32.3 | − 11.3** | −27.9 | |
Month 6 | −1.9** | −13.9 | −2.5** | − 18.3 | − 16.1** | − 39.1 | − 14.9** | − 36.6 | |
Month 9 | − 2.6** | − 18.9 | − 3.9** | −28.0 | − 17.8** | − 43.3 | − 15.3** | − 37.7 | |
Month 12 | − 4.1** | − 29.7 | − 4.2** | − 30.4 | − 19.3** | − 47.0 | − 19.5** | − 47.8 | |
Absenteesim | Baseline, mean | 1.47 | 1.67 | 4.37 | 4.38 | ||||
Month 3 | −0.1 | −5.4 | − 0.4** | −22.2 | −1.1** | − 24.0 | − 1.2** | − 26.3 | |
Month 6 | − 0.1 | −6.1 | − 0.2 | − 12.0 | − 1.5** | −35.2 | − 1.6** | − 35.4 | |
Month 9 | − 0.3* | −17.7 | − 0.3* | −19.8 | − 1.6** | −36.8 | −1.5** | − 35.2 | |
Month 12 | − 0.2 | −10.2 | − 0.4* | − 22.2 | − 1.7** | −39.4 | − 2.0** | − 45.2 | |
Presenteeism | Baseline, mean | 2.77 | 3.02 | 9.00 | 8.70 | ||||
Month 3 | −0.02 | − 0.7 | − 0.2 | −7.6 | −2.7** | − 29.9 | − 2.3** | − 26.0 | |
Month 6 | − 0.1 | −4.7 | − 0.3 | −9.6 | −3.6** | − 39.7 | − 3.1** | − 35.6 | |
Month 9 | − 0.3 | − 10.5 | − 0.8** | −24.8 | −3.9** | − 43.1 | − 2.8** | −31.8 | |
Month 12 | − 0.6* | − 23.1 | − 0.6* | − 20.5 | − 4.1** | − 45.4 | −3.9** | − 44.3 | |
Headache daysa | Baseline, mean | 11.05 | 10.92 | 18.89 | 19.14 | ||||
Month 3 | −2.7** | −24.7 | − 2.1** | −19.5 | −4.1** | − 21.7 | −5.2** | −27.4 | |
Month 6 | −2.8** | −25.0 | − 2.2** | −20.4 | − 5.8** | −30.8 | − 5.5** | −28.9 | |
Month 9 | −3.7** | −33.6 | − 3.4** | − 31.1 | −6.4** | − 34.1 | − 7.6** | −39.9 | |
Month 12 | −4.6** | −41.2 | −3.3** | −30.0 | −6.6** | − 34.9 | −8.4** | − 43.9 | |
Average headache pain intensitya | Baseline, mean | 7.32 | 7.14 | 7.46 | 7.49 | ||||
Month 3 | −0.4* | −4.9 | − 0.4** | −5.9 | − 0.4** | − 5.8 | − 0.4** | − 5.6 | |
Month 6 | −0.7** | −10.1 | − 0.6** | −8.0 | −0.6** | − 8.3 | − 0.7** | −9.9 | |
Month 9 | −0.8** | − 10.4 | −1.0** | − 14.1 | − 0.8** | −10.3 | − 0.8** | − 10.0 | |
Month 12 | −1.0** | − 13.8 | −1.2** | − 16.7 | −1.2** | − 16.1 | −1.3** | − 17.0 |