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Table 5 Change from baseline in MIDAS response by baseline MIDAS disability severity (<21 vs. ≥21)

From: Trajectory of migraine-related disability following long-term treatment with lasmiditan: results of the GLADIATOR study

  

MIDAS total < 21 at baseline

MIDAS total ≥ 21 at baseline

Lasmiditan 100 mg (n = 418)

Lasmiditan 200 mg (n = 465)

Lasmiditan 100 mg (n = 554)

Lasmiditan 200 mg(n = 598)

 

LS mean

% change in mean

LS mean

% change in mean

LS mean

% change in mean

LS mean

% change in mean

MIDAS Total

Baseline, mean

13.8

13.8

41.1

40.7

Month 3

−0.6

−4.2

−1.7**

−12.5

−13.3**

−32.3

− 11.3**

−27.9

Month 6

−1.9**

−13.9

−2.5**

− 18.3

− 16.1**

− 39.1

− 14.9**

− 36.6

Month 9

− 2.6**

− 18.9

− 3.9**

−28.0

− 17.8**

− 43.3

− 15.3**

− 37.7

Month 12

− 4.1**

− 29.7

− 4.2**

− 30.4

− 19.3**

− 47.0

− 19.5**

− 47.8

Absenteesim

Baseline, mean

1.47

1.67

4.37

4.38

Month 3

−0.1

−5.4

− 0.4**

−22.2

−1.1**

− 24.0

− 1.2**

− 26.3

Month 6

− 0.1

−6.1

− 0.2

− 12.0

− 1.5**

−35.2

− 1.6**

− 35.4

Month 9

− 0.3*

−17.7

− 0.3*

−19.8

− 1.6**

−36.8

−1.5**

− 35.2

Month 12

− 0.2

−10.2

− 0.4*

− 22.2

− 1.7**

−39.4

− 2.0**

− 45.2

Presenteeism

Baseline, mean

2.77

3.02

9.00

8.70

Month 3

−0.02

− 0.7

− 0.2

−7.6

−2.7**

− 29.9

− 2.3**

− 26.0

Month 6

− 0.1

−4.7

− 0.3

−9.6

−3.6**

− 39.7

− 3.1**

− 35.6

Month 9

− 0.3

− 10.5

− 0.8**

−24.8

−3.9**

− 43.1

− 2.8**

−31.8

Month 12

− 0.6*

− 23.1

− 0.6*

− 20.5

− 4.1**

− 45.4

−3.9**

− 44.3

Headache daysa

Baseline, mean

11.05

10.92

18.89

19.14

Month 3

−2.7**

−24.7

− 2.1**

−19.5

−4.1**

− 21.7

−5.2**

−27.4

Month 6

−2.8**

−25.0

− 2.2**

−20.4

− 5.8**

−30.8

− 5.5**

−28.9

Month 9

−3.7**

−33.6

− 3.4**

− 31.1

−6.4**

− 34.1

− 7.6**

−39.9

Month 12

−4.6**

−41.2

−3.3**

−30.0

−6.6**

− 34.9

−8.4**

− 43.9

Average headache pain intensitya

Baseline, mean

7.32

7.14

7.46

7.49

Month 3

−0.4*

−4.9

− 0.4**

−5.9

− 0.4**

− 5.8

− 0.4**

− 5.6

Month 6

−0.7**

−10.1

− 0.6**

−8.0

−0.6**

− 8.3

− 0.7**

−9.9

Month 9

−0.8**

− 10.4

−1.0**

− 14.1

− 0.8**

−10.3

− 0.8**

− 10.0

Month 12

−1.0**

− 13.8

−1.2**

− 16.7

−1.2**

− 16.1

−1.3**

− 17.0

  1. *p < .05; **p < .001. aNot included in MIDAS total score. Abbreviations: BL = baseline; LS mean = least squares mean; n = number of patients in subgroup