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Table 1 Baseline characteristics by lasmiditan dose for the GLADIATOR MIDAS population

From: Trajectory of migraine-related disability following long-term treatment with lasmiditan: results of the GLADIATOR study

ParameterLasmiditan 100 mg
(N = 974)
Lasmiditan 200 mg
(N = 1063)
Age, mean years (SD)42.8 (12.3)43.6 (12.4)
Female, n (%)828 (85.0)904 (85.0)
Body mass index, kg/m2 (SD)31.1 (8.2)31.0 (8.1)
Race
 White, n (%)744 (76.4)837 (78.7)
 African American, n (%)193 (19.8)181 (17.0)
 Other, n (%)37 (3.8)43 (4.0)
 Duration of migraine, mean years (SD)18.8 (12.8)18.8 (12.9)
 Migraine attacks/month, mean n (SD)a5.2 (1.8)5.2 (1.8)
 Migraine with aurab,c, n (%)356 (36.6)366 (34.5)
 Migraine preventive medication use, n (%)214 (22.0)234 (22.0)
Patients with CV risk factorsb,d,  n (%)
  ≥ 1814 (83.6)852 (80.2)
  ≥ 2482 (49.5)519 (48.8)
MIDAS questionnaire
 MIDAS total scoree, mean (IQR)29.4 (15, 36)28.9 (15, 35)
 Headache days in past 3 months, mean (IQR)f15.5 (8, 20)15.5 (8, 20)
 Severity of headache paing, mean (IQR)7.4 (7, 8)7.3 (6, 8)
  1. Abbreviations: CAD coronary artery disease; CV cardiovascular; IQR interquartile range; MIDAS Migraine Disability Assessment; SD standard deviation
  2. aBased on response to the question in migraine history section of the case report form “Frequency of migraine attacks (average) during the last three months.” bData from parent study. cFulfilling ICHD criteria 1.2.1 for migraine with typical aura. dHypertension, hypercholesterolemia, smoking, obesity, diabetes mellitus, family history of CAD, men over 40 years of age, and postmenopausal women. eCalculated as the sum of the answers to the 5 questions on the MIDAS questionnaire (0–5 = little or no disability; 6–10 = mild disability; 11–20 = moderate disability; ≥21 = severe disability; >40 = very severe disability). f“On how many days in the past 3 months did you have a headache? (If a headache lasted more than 1 day, count each day)”. g“On a scale of 0 to 10, on average how painful were these headaches? (where 0 = no pain at all, and 10 = pain as bad as it can be)”
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