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Table 6 Combination of genetic polymorphisms to predict risk of migraine. Calculation of joint PAR% using the SNPs showing noteworthiness during the computing of BFDP (BFDP < 0.8) or FPRP (FPRP< 0.2) at a statistical power to detect the OR of 1.5

From: Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Author, year

Gene/variant

Comparison

MAF

OR (95%CI)

P-value

Ethnicity

No. of cases/controls

PAR (%)

Joint PAR (%)

Chang X, 2018 [45]

NMUR2/rs72793414

A vs. G

0.1082

2.44 (1.85–3.23)

3.81E-10

Overall 2

1212/13494

13.4804396578

44.2094776354

Gormley P, 2016 [40]

LRP1/rs11172113

C vs. T

0.3894

0.90 (0.89–0.91)

5.6E-49

Caucasian 22

59,674/316078

4.0517761638

 

Gormley P, 2016 [40]

PRDM 16/rs10218452

G vs. A

0.2264

1.11 (1.10–1.13)

5.3E-38

Caucasian 22

59,674/316078

2.4298861162

 

Gormley P, 2016 [40]

FHL5/rs67338227

T vs. A

0.0220

1.09 (1.08–1.11)

2.0E-27

Caucasian 22

59,674/316078

0.1976087347

 

Gormley P, 2016 [40]

TSPAN2/rs2078371

C vs. T

0.1252

1.11 (1.09–1.13)

4.1E-24

Caucasian 22

59,674/316078

1.3584908638

 

Gormley P, 2016 [40]

PHACTR1/rs9349379

G vs. A

0.3774

0.93 (0.92–0.95)

5.8E-22

Caucasian 22

59,674/316078

2.7134848426

 

Gormley P, 2016 [40]

MEF2D/rs1925950

A vs. G

0.4277

1.07 (1.06–1.09)

9.1E-22

Caucasian 22

59,674/316078

2.9068711836

 

Gormley P, 2016 [40]

SLC24A3/rs4814864

C vs. G

0.3021

1.07 (1.06–1.09)

2.2E-19

Caucasian 22

59,674/316078

2.0709065394

 

Gormley P, 2016 [40]

FGF6/rs1024905

A vs. G

0.3165

1.06 (1.04–1.08)

2.1E-17

Caucasian 22

59,674/316078

1.8636100452

 

Gormley P, 2016 [40]

C7orf10/rs186166891

T vs. A

0.1631

1.09 (1.07–1.12)

9.7E-16

Caucasian 22

59,674/316078

1.4466644131

 

Gormley P, 2016 [40]

PLCE1/rs10786156

G vs. C

0.4852

0.95 (0.94–0.96)

2.0E-14

Caucasian 22

59,674/316078

2.4863180765

 

Gormley P, 2016 [40]

KCNK5/rs10456100

T vs. C

0.1813

1.06 (1.04–1.07)

6.9E-13

Caucasian 22

59,674/316078

1.0760942468

 

Gormley P, 2016 [40]

HPSE2/rs12260159

A vs. G

0.1673

0.92 (0.89–0.94)

3.2E-10

Caucasian 22

59,674/316078

1.3565561475

 

Gormley P, 2016 [40]

CFDP1/rs77505915

A vs. T

0.4898

1.05 (1.03–1.06)

3.3E-10

Caucasian 22

59,674/316078

2.3904576911

 

Gormley P, 2016 [40]

RNF213/rs17857135

C vs. T

0.2115

1.06 (1.04–1.08)

5.2E-10

Caucasian 22

59,674/316078

1.2530981840

 

Gormley P, 2016 [40]

NRP1/rs2506142

G vs. A

0.1865

1.06 (1.04–1.07)

1.5E-09

Caucasian 22

59,674/316078

1.1066169563

 

Gormley P, 2016 [40]

GPR149/rs13078967

C vs. A

0.0110

0.87 (0.83–0.91)

1.8E-09

Caucasian 22

59,674/316078

0.1432047828

 

Gormley P, 2016 [40]

SPINK2/rs7684253

T vs. C

0.4499

0.96 (0.94–0.97)

2.5E-09

Caucasian 22

59,674/316078

1.8325790934

 

Gormley P, 2016 [40]

HEY2/rs1268083

C vs. T

0.4419

0.96 (0.95–0.97)

5.3E-09

Caucasian 22

59,674/316078

1.7994063059

 

Gormley P, 2016 [40]

WSCD1/rs75213074

T vs. C

0.0094

0.89 (0.86–0.93)

7.1E-09

Caucasian 22

59,674/316078

0.1035070263

 

Gormley P, 2016 [40]

GJA1/rs28455731

T vs. G

0.1302

1.06 (1.04–1.08)

7.3E-09

Caucasian 22

59,674/316078

0.7751445706

 

Gormley P, 2016 [40]

ITPK1/rs11624776

C vs. A

0.2278

0.96 (0.94–0.97)

7.9E-09

Caucasian 22

59,674/316078

0.9195792057

 

Gormley P, 2016 [40]

ADAMTSL4/rs6693567

T vs. C

0.3037

1.05 (1.03–1.06)

1.2E-08

Caucasian 22

59,674/316078

1.4957864823

 

Gormley P, 2016 [40]

MED14/rs12845494

G vs. C

0.4114

0.96 (0.95–0.97)

1.7E-08

Caucasian 22

59,674/316078

1.6731330779

 

Gormley P, 2016 [40]

LRRIQ3/rs1572668

G vs. A

0.4930

1.04 (1.02–1.05)

2.1E-08

Caucasian 22

59,674/316078

1.9338641980

 

Gormley P, 2016 [40]

CARF/rs138556413

G vs. A

0.0104

0.88 (0.84–0.92)

2.3E-08

Caucasian 22

59,674/316078

0.1249559450

 

Gormley P, 2016 [40]

ARMS2/rs2223089

C vs. G

0.1288

0.93 (0.91–0.95)

3.0E-08

Caucasian 22

59,674/316078

0.9098027819

 

Gormley P, 2016 [40]

IGSF9B/rs561561

T vs. A

0.0827

0.94 (0.92–0.96)

3.4E-08

Caucasian 22

59,674/316078

0.4986744225

 

Gormley P, 2016 [40]

NOTCH4/rs140002913

A vs. G

0.1150

0.91 (0.88–0.94)

3.8E-08

Caucasian 22

59,674/316078

1.0458242813

 

Anttila V. 2013 [29]

PRDM16/rs2651899

C vs. T

0.4708

1.09 (1.07–1.12)

3.28E-14

Caucasian 19

23,285/95425

4.0649595346

 

Anttila V. 2013 [29]

TSPAN2/rs12134493

A vs. C

0.0709

1.14 (1.10–1.18)

6.71E-14

Caucasian 19

23,285/95425

0.9828442876

 

Anttila V. 2013 [29]

MEF2D/rs2274316

C vs. A

0.4289

1.07 (1.04–1.09)

3.14E-08

Caucasian 19

23,285/95425

2.9147892814

 

Anttila V. 2013 [29]

TRPM8/rs7577262

A vs. G

0.2356

0.87 (0.84–0.90)

3.27E-13

Caucasian 19

23,285/95425

3.1595713513

 

Anttila V. 2013 [29]

FHL5/rs13208321

A vs. T

0.2949

1.18 (1.13–1.24)

2.15E-12

Caucasian 19

23,285/95425

5.0406331131

 

Anttila V. 2013 [29]

c7orf10/rs4379368

T vs. C

0.1961

1.11 (1.08–1.15)

1.46E-09

Caucasian 19

23,285/95425

2.1115517179

 

Anttila V. 2013 [29]

MTDH/rs1835740

C vs. T

0.3510

1.18 (1.13–1.24)

1.60E-11

Caucasian 7

5950/50809

5.9425497094

 
  1. MAF minor allelic frequency, PAR population attributable risk
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