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Table 6 Combination of genetic polymorphisms to predict risk of migraine. Calculation of joint PAR% using the SNPs showing noteworthiness during the computing of BFDP (BFDP < 0.8) or FPRP (FPRP< 0.2) at a statistical power to detect the OR of 1.5

From: Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Author, yearGene/variantComparisonMAFOR (95%CI)P-valueEthnicityNo. of cases/controlsPAR (%)Joint PAR (%)
Chang X, 2018 [45]NMUR2/rs72793414A vs. G0.10822.44 (1.85–3.23)3.81E-10Overall 21212/1349413.480439657844.2094776354
Gormley P, 2016 [40]LRP1/rs11172113C vs. T0.38940.90 (0.89–0.91)5.6E-49Caucasian 2259,674/3160784.0517761638 
Gormley P, 2016 [40]PRDM 16/rs10218452G vs. A0.22641.11 (1.10–1.13)5.3E-38Caucasian 2259,674/3160782.4298861162 
Gormley P, 2016 [40]FHL5/rs67338227T vs. A0.02201.09 (1.08–1.11)2.0E-27Caucasian 2259,674/3160780.1976087347 
Gormley P, 2016 [40]TSPAN2/rs2078371C vs. T0.12521.11 (1.09–1.13)4.1E-24Caucasian 2259,674/3160781.3584908638 
Gormley P, 2016 [40]PHACTR1/rs9349379G vs. A0.37740.93 (0.92–0.95)5.8E-22Caucasian 2259,674/3160782.7134848426 
Gormley P, 2016 [40]MEF2D/rs1925950A vs. G0.42771.07 (1.06–1.09)9.1E-22Caucasian 2259,674/3160782.9068711836 
Gormley P, 2016 [40]SLC24A3/rs4814864C vs. G0.30211.07 (1.06–1.09)2.2E-19Caucasian 2259,674/3160782.0709065394 
Gormley P, 2016 [40]FGF6/rs1024905A vs. G0.31651.06 (1.04–1.08)2.1E-17Caucasian 2259,674/3160781.8636100452 
Gormley P, 2016 [40]C7orf10/rs186166891T vs. A0.16311.09 (1.07–1.12)9.7E-16Caucasian 2259,674/3160781.4466644131 
Gormley P, 2016 [40]PLCE1/rs10786156G vs. C0.48520.95 (0.94–0.96)2.0E-14Caucasian 2259,674/3160782.4863180765 
Gormley P, 2016 [40]KCNK5/rs10456100T vs. C0.18131.06 (1.04–1.07)6.9E-13Caucasian 2259,674/3160781.0760942468 
Gormley P, 2016 [40]HPSE2/rs12260159A vs. G0.16730.92 (0.89–0.94)3.2E-10Caucasian 2259,674/3160781.3565561475 
Gormley P, 2016 [40]CFDP1/rs77505915A vs. T0.48981.05 (1.03–1.06)3.3E-10Caucasian 2259,674/3160782.3904576911 
Gormley P, 2016 [40]RNF213/rs17857135C vs. T0.21151.06 (1.04–1.08)5.2E-10Caucasian 2259,674/3160781.2530981840 
Gormley P, 2016 [40]NRP1/rs2506142G vs. A0.18651.06 (1.04–1.07)1.5E-09Caucasian 2259,674/3160781.1066169563 
Gormley P, 2016 [40]GPR149/rs13078967C vs. A0.01100.87 (0.83–0.91)1.8E-09Caucasian 2259,674/3160780.1432047828 
Gormley P, 2016 [40]SPINK2/rs7684253T vs. C0.44990.96 (0.94–0.97)2.5E-09Caucasian 2259,674/3160781.8325790934 
Gormley P, 2016 [40]HEY2/rs1268083C vs. T0.44190.96 (0.95–0.97)5.3E-09Caucasian 2259,674/3160781.7994063059 
Gormley P, 2016 [40]WSCD1/rs75213074T vs. C0.00940.89 (0.86–0.93)7.1E-09Caucasian 2259,674/3160780.1035070263 
Gormley P, 2016 [40]GJA1/rs28455731T vs. G0.13021.06 (1.04–1.08)7.3E-09Caucasian 2259,674/3160780.7751445706 
Gormley P, 2016 [40]ITPK1/rs11624776C vs. A0.22780.96 (0.94–0.97)7.9E-09Caucasian 2259,674/3160780.9195792057 
Gormley P, 2016 [40]ADAMTSL4/rs6693567T vs. C0.30371.05 (1.03–1.06)1.2E-08Caucasian 2259,674/3160781.4957864823 
Gormley P, 2016 [40]MED14/rs12845494G vs. C0.41140.96 (0.95–0.97)1.7E-08Caucasian 2259,674/3160781.6731330779 
Gormley P, 2016 [40]LRRIQ3/rs1572668G vs. A0.49301.04 (1.02–1.05)2.1E-08Caucasian 2259,674/3160781.9338641980 
Gormley P, 2016 [40]CARF/rs138556413G vs. A0.01040.88 (0.84–0.92)2.3E-08Caucasian 2259,674/3160780.1249559450 
Gormley P, 2016 [40]ARMS2/rs2223089C vs. G0.12880.93 (0.91–0.95)3.0E-08Caucasian 2259,674/3160780.9098027819 
Gormley P, 2016 [40]IGSF9B/rs561561T vs. A0.08270.94 (0.92–0.96)3.4E-08Caucasian 2259,674/3160780.4986744225 
Gormley P, 2016 [40]NOTCH4/rs140002913A vs. G0.11500.91 (0.88–0.94)3.8E-08Caucasian 2259,674/3160781.0458242813 
Anttila V. 2013 [29]PRDM16/rs2651899C vs. T0.47081.09 (1.07–1.12)3.28E-14Caucasian 1923,285/954254.0649595346 
Anttila V. 2013 [29]TSPAN2/rs12134493A vs. C0.07091.14 (1.10–1.18)6.71E-14Caucasian 1923,285/954250.9828442876 
Anttila V. 2013 [29]MEF2D/rs2274316C vs. A0.42891.07 (1.04–1.09)3.14E-08Caucasian 1923,285/954252.9147892814 
Anttila V. 2013 [29]TRPM8/rs7577262A vs. G0.23560.87 (0.84–0.90)3.27E-13Caucasian 1923,285/954253.1595713513 
Anttila V. 2013 [29]FHL5/rs13208321A vs. T0.29491.18 (1.13–1.24)2.15E-12Caucasian 1923,285/954255.0406331131 
Anttila V. 2013 [29]c7orf10/rs4379368T vs. C0.19611.11 (1.08–1.15)1.46E-09Caucasian 1923,285/954252.1115517179 
Anttila V. 2013 [29]MTDH/rs1835740C vs. T0.35101.18 (1.13–1.24)1.60E-11Caucasian 75950/508095.9425497094 
  1. MAF minor allelic frequency, PAR population attributable risk
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