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Table 5 Subgroup analysis results of genetic variants with statistically significance (P-value< 5*10−8) from GWAS studies based on migraine subtype

From: Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Author, year Gene/variant Comparison OR (95%CI) P-value Subtypes No. of cases/controls FPRP Values at Prior probability BFDP 0.001 BFDP 0.000001
OR 1.2 OR 1.5
0.001 0.000001 0.001 0.000001
Gormley P, 2016 [40] LRP1/rs11172113 C vs. T 0.85 (0.82–0.89) 4.3E-16 MO 8348/139622 5.365E-09 5.370E-06 4.295E-09 4.300E-06 4.578E-07 4.580E-04
Gormley P, 2016 [40] FHL5/rs7775721 T vs. A 1.15 (1.11–1.20) 1.1E-12 MO 8348/139622 1.253E-07 1.254E-04 1.222E-07 1.223E-04 1.210E-05 0.012
Gormley P, 2016 [40] ASTN2/rs6478241 G vs. A 1.14 (1.09–1.18) 1.2E-10 MO 8348/139622 9.555E-11 9.565E-08 9.538E-11 9.548E-08 1.305E-08 1.307E-05
Gormley P, 2016 [40] TRPM8/rs6724624 G vs. C 0.86 (0.82–0.90) 1.1E-09 MO 8348/139622 8.654E-08 8.662E-05 7.899E-08 7.906E-05 7.681E-06 7.630E-03
Gormley P, 2016 [40] PHACTR1/rs9349379 G vs. A 0.88 (0.85–0.92) 2.1E-09 MO 8348/139622 1.748E-05 0.017 1.733E-05 0.017 1.395E-03 0.583
Gormley P, 2016 [40] FGF6/rs1024905 A vs. G 1.12 (1.08–1.16) 2.5E-09 MO 8348/139622 2.451E-07 2.453E-04 2.451E-07 2.453E-04 2.680E-05 0.026
Gormley P, 2016 [40] TSPAN2/rs2078371 C vs. T 1.18 (1.12–1.25) 7.4E-09 MO 8348/139622 2.525E-05 0.025 1.808E-05 0.018 1.276E-03 0.561
Anttila V, 2013 [29] TRPM8/rs6741751 A vs. G 0.80 (0.75–0.86) 8.64E-11 MO 7107/69427 1.094E-05 0.011 1.469E-06 1.469E-03 1.143E-04 0.103
Anttila V, 2013 [29] LRP1/rs11172113 C vs. T 0.87 (0.84–0.91) 9.96E-11 MO 7107/69427 1.300E-06 1.300E-03 1.260E-06 1.260E-03 1.117E-04 0.101
Anttila V, 2013 [29] PHACTR1/rs9349379 G vs. A 0.86 (0.82–0.90) 2.81E-10 MO 7107/69427 8.654E-08 8.662E-05 7.899E-08 7.906E-05 7.681E-06 7.630E-03
Anttila V, 2013 [29] FHL5/rs11759769 A vs. G 1.18 (1.13–1.24) 1.58E-12 MO 7107/69427 8.181E-08 8.189E-05 6.109E-08 6.115E-05 5.781E-06 5.753E-03
Anttila V, 2013 [29] MMP16/rs10504861 T vs. C 0.86 (0.81–0.90) 1.17E-08 MO 7107/69427 8.654E-08 8.662E-05 7.899E-08 7.906E-05 7.681E-06 7.630E-03
  1. GWAS genome-wide association studies, MO migraine without aura