Skip to main content

Table 1 Meta-analyses results of genetic variants with statistically significance (P-value< 0.05) from observational studies

From: Genetic variants in migraine: a field synopsis and systematic re-analysis of meta-analyses

Author, year

Gene/variant

Comparison

OR (95%CI)

P-Value

Ethnicity

No. of cases/controls

FPRP Values at Prior probability

BFDP 0.05

BFDP 0.001

Venice criteria

Venice criteria score

OR 1.2

OR 1.5

0.05

0.001

0.05

0.001

Liu L, 2019 [48]

MTHFR/rs1801133

T vs. C

1.19 (1.06–1.33)

0.004

Overall 26 (Caucasian 20, Asian 6)

10,228/28608

0.069

0.795

0.040

0.685

0.476

0.980

A + C + C

Low

Liu L, 2019 [48]

MTHFR/rs1801133

TT vs. CT + CC

1.29 (1.06–1.56)

0.010

Overall 26 (Caucasian 20, Asian 6)

10,228/28608

0.419

0.974

0.149

0.902

0.726

0.993

A + C + C

Low

Liu L, 2019 [48]

MTHFR/rs1801133

TT + CT vs. CC

1.17 (1.02–1.35)

0.027

Overall 26 (Caucasian 20, Asian 6)

10,228/28608

0.485

0.980

0.375

0.969

0.880

0.997

A + C + C

Low

Liu L, 2019 [48]

MTHFR/rs1801133

TT vs. CC

1.32 (1.07–1.64)

0.011

Overall 26 (Caucasian 20, Asian 6)

10,228/28608

0.543

0.984

0.209

0.933

0.778

0.995

A + C + C

Low

Liu L, 2019 [48]

MTHFR/rs1801131

CC vs. AC + AA

1.82 (1.09–3.04)

0.022

Overall 5 (Caucasian 4, Asian 1)

1368/1411

0.883

0.998

0.647

0.990

0.899

0.998

A + C + C

Low

Liu L, 2019 [48]

MTHFR/rs1801131

CC vs. AA

1.78 (1.03–3.07)

0.038

Overall 5 (Caucasian 4, Asian 1)

1368/1411

0.903

0.998

0.729

0.993

0.917

0.998

A + C + C

Low

Gao X, 2018 [47]

GRIA1/rs2195450

CT vs. CC

1.23 (1.02–1.48)

0.03

Overall 4 (Caucasian 3, Asian 1)

963/1167

0.576

0.986

0.354

0.966

0.862

0.997

A + B + A

Intermediate

Terrazzino S, 2017 [44]

BDNF/rs6265

A vs. G

1.17 (1.03–1.34)

0.014

Overall 5 (Caucasian 5)

2884/3760

0.408

0.973

0.307

0.959

0.856

0.997

A + A + A

High

Terrazzino S, 2017 [44]

BDNF/rs6265

AA + GA vs. GG

1.22 (1.05–1.41)

0.011

Overall 5 (Caucasian 5)

2884/3760

0.247

0.945

0.119

0.877

0.694

0.992

A + A + A

High

Cai X, 2017 [42]

BDNF/rs2049046

A vs. T

0.88 (0.79–0.98)

0.02

Overall 4 (Caucasian 4)

1260/1380

0.311

0.960

0.275

0.952

0.855

0.997

A + A + C

Low

Cai X, 2017 [42]

BDNF/rs2049046

AA vs. TA + TT

0.80 (0.67–0.96)

0.02

Overall 4 (Caucasian 4)

1260/1380

0.486

0.980

0.243

0.944

0.809

0.996

A + A + A

High

Cai X, 2017 [42]

BDNF/rs2049046

AA vs. TT

0.78 (0.62–0.97)

0.02

Overall 4 (Caucasian 4)

1260/1380

0.637

0.989

0.345

0.965

0.853

0.997

A + A + A

High

Cai X, 2017 [42]

BDNF/rs2049046

AA vs. TA

0.81 (0.67–0.99)

0.03

Overall 4 (Caucasian 4)

1260/1380

0.658

0.990

0.436

0.976

0.887

0.998

A + A + A

High

Li L, 2015 [37]

ESR1/rs1801132

GG vs. CC

1.51 (1.15–1.99)

0.003

Overall 5 (Caucasian 4, Asian 1)

2027/1919

0.559

0.985

0.119

0.877

0.644

0.990

A + A + A

High

Li L, 2015 [37]

ESR1/rs1801132

GG vs. CG + CC

1.52 (1.16–1.98)

0.002

Overall 5 (Caucasian 4, Asian 1)

2027/1919

0.477

0.980

0.073

0.805

0.542

0.984

A + B + A

Intermediate

Li L, 2015 [37]

ESR1/rs2228480

AG vs. GG

1.14 (1.01–1.28)

0.030

Overall 6 (Caucasian 5, Asian 1)

2293/2026

0.385

0.971

0.336

0.964

0.877

0.997

A + A + A

High

Li L, 2015 [37]

ESR1/rs2228480

AA + AG vs. GG

1.13 (1.00–1.26)

0.003

Overall 6 (Caucasian 5, Asian 1)

2293/2026

0.381

0.970

0.346

0.965

0.885

0.998

A + B + A

Intermediate

Liu H, 2011 [23]

5-HTT/VNTR

Stin2.12 allele

1.34 (1.09–1.64)

0.006

Overall 4 (Caucasian 3, Asian1)

495/729

0.377

0.970

0.090

0.840

0.628

0.989

A + A + NA

NA

Liu H, 2011 [23]

5-HTT/VNTR

12/12 genotype

1.55 (1.17–2.05)

0.002

Overall 4 (Caucasian 3, Asian1)

495/729

0.526

0.983

0.090

0.838

0.557

0.986

A + A + NA

NA

  1. OR odds radio, CI confidence interval, FPRP false-positive rate probability, BFDP Bayesian false discovery probability, NA not available