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Fig. 8 | The Journal of Headache and Pain

Fig. 8

From: Microglia P2X4R-BDNF signalling contributes to central sensitization in a recurrent nitroglycerin-induced chronic migraine model

Fig. 8

The levels of p38, p-p38-MAPK and BDNF after pharmacological inactivation or activation of P2X4Rs. a Representative images of Western blot results showing the expression of p38, p-p38 and BDNF proteins after 5-BDBD treatment. b-d The histogram presents the quantitative analysis of p-p38 (b), p38MAPK (c) and BDNF (d) in the TNC. n = 5/group. ***p < 0.001 versus VEH-VEH, ###p < 0.001 versus NTG-VEH. (e) Representative images of Western blot results showing the expression of P2X4, p38, p-p38 and BDNF proteins after IVM treatments. f-i The histogram presents the quantitative analysis of P2X4 (f), p38 (g), p-p38 (h) and BDNF (i) in the TNC. Data are presented as the mean ± SD. n = 6–8/group, One-way ANOVA and Tukey’s multiple comparison test. *p < 0.05, **p < 0.01, ***p < 0.001 versus VEH

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