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Table 4 Analyses of carry-over effect: effect of active treatment compared to placebo related to treatment sequence (N = 176)1

From: The crossover design for migraine preventives: an analyses of four randomized placebo-controlled trials

Order of treatmentNumber with complete dataChange in migraine days/4 weeks, mean (95% CI)Change in headache days/4 weeks, mean (95% CI)
Placebo before active treatment80−0.90 (−1.39, −0.40)−1.26 (− 1.95, − 0.57)
Placebo after active treatment96− 1.22 (− 1.69, − 0.74)−0.90 (− 1.58, − 0.23)
P-value2 0.350.46
  1. 12001, 2003 and 2014 data included
  2. 2Evaluated by Student’s t-test
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