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Table 4 Analyses of carry-over effect: effect of active treatment compared to placebo related to treatment sequence (N = 176)1

From: The crossover design for migraine preventives: an analyses of four randomized placebo-controlled trials

Order of treatment

Number with complete data

Change in migraine days/4 weeks, mean (95% CI)

Change in headache days/4 weeks, mean (95% CI)

Placebo before active treatment

80

−0.90 (−1.39, −0.40)

−1.26 (− 1.95, − 0.57)

Placebo after active treatment

96

− 1.22 (− 1.69, − 0.74)

−0.90 (− 1.58, − 0.23)

P-value2

 

0.35

0.46

  1. 12001, 2003 and 2014 data included
  2. 2Evaluated by Student’s t-test
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The Journal of Headache and Pain

ISSN: 1129-2377

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