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Table 3 Demonstration of the associations between chronic migraine and rs10166942 genotypes by logistic regression models

From: TRPM8 genetic variant is associated with chronic migraine and allodynia

 UnivariateMultivariablea
ORp valueORp value
Discovery cohort
 Age1.03< 0.001**1.020.001**
 Sex (female = 1/male = 0)1.290.116
 Education (years)0.92< 0.001**0.83< 0.001**
 Level of anxiety1.06< 0.001**
 Level of depression1.09< 0.001**
 rs10166942 (T carriers =1)1.410.014*1.400.020*
Replication cohort
 Age1.04< 0.001**1.020.006**
 Sex (female = 1/male = 0)1.280.194
 Education (years)0.84< 0.001**0.70< 0.001**
 BMI1.010.517
 Level of anxiety1.050.008**
 Level of depression1.11< 0.001**1.100.001**
 rs10166942 (T carriers =1)1.520.008**1.560.008**
Combined
 Age1.03< 0.001**1.020.019*
 Sex (female = 1/male = 0)1.290.042*
 Education (years)0.89< 0.001**0.71< 0.001**
 BMI1.010.529
 Level of anxiety1.06< 0.001**
 Level of depression1.09< 0.001**1.11< 0.001**
 rs10166942 (T carriers =1)1.460.001**1.620.004**
  1. acontrolled by age, sex and anxious level. OR odds ratio; BMI body mass index; level of anxiety: presented by HADS anxiety score; level of depression: presented by HADS depression score. * indicated p < 0.05; ** indicated p < 0.01. Of note, BMI data were not available in discovery cohort
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