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Table 3 Demonstration of the associations between chronic migraine and rs10166942 genotypes by logistic regression models

From: TRPM8 genetic variant is associated with chronic migraine and allodynia

 

Univariate

Multivariablea

OR

p value

OR

p value

Discovery cohort

 Age

1.03

< 0.001**

1.02

0.001**

 Sex (female = 1/male = 0)

1.29

0.116

–

–

 Education (years)

0.92

< 0.001**

0.83

< 0.001**

 Level of anxiety

1.06

< 0.001**

–

–

 Level of depression

1.09

< 0.001**

–

–

 rs10166942 (T carriers =1)

1.41

0.014*

1.40

0.020*

Replication cohort

 Age

1.04

< 0.001**

1.02

0.006**

 Sex (female = 1/male = 0)

1.28

0.194

–

–

 Education (years)

0.84

< 0.001**

0.70

< 0.001**

 BMI

1.01

0.517

–

–

 Level of anxiety

1.05

0.008**

–

–

 Level of depression

1.11

< 0.001**

1.10

0.001**

 rs10166942 (T carriers =1)

1.52

0.008**

1.56

0.008**

Combined

 Age

1.03

< 0.001**

1.02

0.019*

 Sex (female = 1/male = 0)

1.29

0.042*

–

–

 Education (years)

0.89

< 0.001**

0.71

< 0.001**

 BMI

1.01

0.529

–

–

 Level of anxiety

1.06

< 0.001**

–

–

 Level of depression

1.09

< 0.001**

1.11

< 0.001**

 rs10166942 (T carriers =1)

1.46

0.001**

1.62

0.004**

  1. acontrolled by age, sex and anxious level. OR odds ratio; BMI body mass index; level of anxiety: presented by HADS anxiety score; level of depression: presented by HADS depression score. * indicated p < 0.05; ** indicated p < 0.01. Of note, BMI data were not available in discovery cohort
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The Journal of Headache and Pain

ISSN: 1129-2377

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