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Table 2 Migraine endophenotypes and TRPM8 genotyping in participants

From: TRPM8 genetic variant is associated with chronic migraine and allodynia

 Discovery cohort (N = 1077)Replication cohort (N = 827)Combined
 T/T or T/C
n = 681 (63.2%)
C/C
n = 396 (36.8%)
p valueT/T or T/C
n = 495
(59.8%)
C/C
n = 332 (40.2%)
p valuep value
Age38.2 ± 12.837.3 ± 12.20.21937.1 ± 11.936.9 ± 11.40.8610.267
Gender- female515 (75.6)312 (78.8)0.236398 (80.4)255 (76.8)0.2140.899
Presence of aura102 (15.0)78 (19.7)0.04591 (18.4)69 (20.8)0.3920.036
Chronic migraine228 (33.5)104 (26.3)0.013168 (33.9)84 (25.3)0.008< 0.001*
Unilaterality513 (75.3)303 (76.5)0.662406 (82.0)273 (82.2)0.9390.676
Pulsatility500 (74.5)291 (74.4)0.974386 (78.0)256 (77.1)0.7680.923
Aggravation by or avoidance of physical activity599 (89.4)346 (89.2)0.908441 (89.1)276 (83.1)0.0130.057
Nausea589 (87.5)350 (89.3)0.389445 (89.9)297 (89.5)0.8380.823
Vomiting305 (45.3)177 (45.2)0.958263 (53.1)165 (49.7)0.3330.826
Photophobia342 (50.8)188 (48.1)0.390246 (49.7)158 (47.6)0.5520.512
Phonophobia507 (75.3)294 (75.0)0.903359 (72.5)234 (70.5)0.5230.839
Allodynia severity3.5 ± 3.72.6 ± 2.8< 0.001*
  1. Data were presented as n (%) or mean ± SD. T/T: TT homozygous group; T/C: TC or CT heterozygous group; C/C: CC homozygous group; HADS: hospital anxiety and depression scale; * significant after Bonferroni correction (p < 0.05/12 = 0.0042); allodynia severity was presented with the total allodynia scores
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