Table 2 Migraine endophenotypes and TRPM8 genotyping in participants
From: TRPM8 genetic variant is associated with chronic migraine and allodynia
| Discovery cohort (N = 1077) | Replication cohort (N = 827) | Combined | |||||
|---|---|---|---|---|---|---|---|
| T/T or T/C n = 681 (63.2%) | C/C n = 396 (36.8%) | p value | T/T or T/C n = 495 (59.8%) | C/C n = 332 (40.2%) | p value | p value | |
| Age | 38.2 ± 12.8 | 37.3 ± 12.2 | 0.219 | 37.1 ± 11.9 | 36.9 ± 11.4 | 0.861 | 0.267 |
| Gender- female | 515 (75.6) | 312 (78.8) | 0.236 | 398 (80.4) | 255 (76.8) | 0.214 | 0.899 |
| Presence of aura | 102 (15.0) | 78 (19.7) | 0.045 | 91 (18.4) | 69 (20.8) | 0.392 | 0.036 |
| Chronic migraine | 228 (33.5) | 104 (26.3) | 0.013 | 168 (33.9) | 84 (25.3) | 0.008 | < 0.001* |
| Unilaterality | 513 (75.3) | 303 (76.5) | 0.662 | 406 (82.0) | 273 (82.2) | 0.939 | 0.676 |
| Pulsatility | 500 (74.5) | 291 (74.4) | 0.974 | 386 (78.0) | 256 (77.1) | 0.768 | 0.923 |
| Aggravation by or avoidance of physical activity | 599 (89.4) | 346 (89.2) | 0.908 | 441 (89.1) | 276 (83.1) | 0.013 | 0.057 |
| Nausea | 589 (87.5) | 350 (89.3) | 0.389 | 445 (89.9) | 297 (89.5) | 0.838 | 0.823 |
| Vomiting | 305 (45.3) | 177 (45.2) | 0.958 | 263 (53.1) | 165 (49.7) | 0.333 | 0.826 |
| Photophobia | 342 (50.8) | 188 (48.1) | 0.390 | 246 (49.7) | 158 (47.6) | 0.552 | 0.512 |
| Phonophobia | 507 (75.3) | 294 (75.0) | 0.903 | 359 (72.5) | 234 (70.5) | 0.523 | 0.839 |
| Allodynia severity | – | – | – | 3.5 ± 3.7 | 2.6 ± 2.8 | < 0.001* | – |
