Fig. 6

Simulation of neuronal firing. A single compartment neuron was simulated with the program Neuron as described in methods, with a “WT” like Na⁺ channel (without persistent currents) and with a Na⁺ channels with 5% persistent currents, each in the absence and presence of GS967. Each pane (a-d) shows on the left the membrane potential as a function of time for current injections of 120 and 140 pA, and on the right the K⁺ and Na⁺ currents of a single action potential. In panel e the integrated K⁺ efflux during the 400 ms stimulation period is shown as a function of the injected current for the indicated conditions