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Fig. 6 | The Journal of Headache and Pain

Fig. 6

From: Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene

Fig. 6

Simulation of neuronal firing. A single compartment neuron was simulated with the program Neuron as described in methods, with a “WT” like Na+ channel (without persistent currents) and with a Na+ channels with 5% persistent currents, each in the absence and presence of GS967. Each pane (a-d) shows on the left the membrane potential as a function of time for current injections of 120 and 140 pA, and on the right the K+ and Na+ currents of a single action potential. In panel e the integrated K+ efflux during the 400 ms stimulation period is shown as a function of the injected current for the indicated conditions

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