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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene

Fig. 3

GS967 blocks persistent currents for WT and all mutants. a-h show typical voltage clamp current responses to a −30 mV (E), − 25 mV (A, B, C, D, F) or − 10 mV (G, H) pulse before (black traces) and after application of 5 μM GS967. The different voltages were chosen to maximize current amplitudes, which depended on the reversal potential. In particular, oocytes expressing mutants with large persistent currents had a negatively shifted reversal potential due to sodium accumulation. In panel i the average reduction induced by GS967 of peak currents and current at the end of the 70 ms test pulse is expressed as I (after GS967 application) / I (before application). j and k show relative persistent currents before (j) and after (k) application of GS967. GS967 significantly decreases persistent currents at all voltages (p < 0.05)

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