Skip to main content
Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Late sodium current blocker GS967 inhibits persistent currents induced by familial hemiplegic migraine type 3 mutations of the SCN1A gene

Fig. 1

Mapping of mutants on the Na+ channel structure. The structure of the human skeletal muscle sodium channel Nav1.4 [32] is shown in cartoon structure. Domains I-III are shown in gray (voltage-sensor domains in dark gray, pore domains in light gray). The linker between domain III and IV is shown in green. For domain IV, the voltage sensor domain (S1-S4) is shown in dark blue, the pore domain in light blue and the linker S4-S5 in yellow. Residues corresponding to those studied here are shown in space fill: Q1489: light pink; I1498: red; F1499: green; M1500: light brown; L1649: orange; F1661: pink; F1774: yellow

Back to article page
\