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Fig. 7 | The Journal of Headache and Pain

Fig. 7

From: C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

Fig. 7

Schematic overview of the possible modulation by C-fibers on adjacent Aδ-fibers through axon-axon signaling at nodes of Ranvier in the trigeminal system. CGRP is released from the C-fiber bouton and diffuses into the node of Ranvier. Activation of the CGRP receptor causes increase in cyclic AMP, which could alter the conductivity of Na+ or K+ channels through Phosphokinase A (PKA). Furthermore, there is a possibility that 5-HT receptors could negatively modulate the cyclic AMP at the node. Alterations in Na+ or K+ channels could modulate the nodal threshold of activation. The schematic also includes a hypothesis on the mode of action of the anti-migraine antibody treatments

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