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Fig. 3 | The Journal of Headache and Pain

Fig. 3

From: C-fibers may modulate adjacent Aδ-fibers through axon-axon CGRP signaling at nodes of Ranvier in the trigeminal system

Fig. 3

Localization of CGRP receptor and PKA at the nodes of Ranvier in trigeminal axons. CGRP receptors were labeled using a RAMP1 antibody (a) or the AA58 antibody targeted to the functional CGRP receptor complex (b). Both antibodies showed co-localization with CASPR. Evidence of relevant signaling pathways is indicated by positive staining for the catalytic subunit of Protein Kinase A (PKA) at the nodes (c). Arrows indicate the node of Ranvier

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