Reduced resting-state brain functional network connectivity and poor regional homogeneity in patients with CADASIL

Table 5 Significant inter-group differences in ReHo and seed-based FC analysis between CADASIL patients and controls

Predominant cluster regions	Cluster size	Peak T value	MNI coordinates			Cluster level PFWE-corr
Predominant cluster regions	Cluster size	Peak T value	x	y	z	Cluster level PFWE-corr
ReHo reduction in CADASIL patients
Right Pcu/CU	155	−5.33	6	−78	30	0.009
Right visual association cortex
Right calcarine gyri
Right posterior cingulate
Right limbic lobe
FC reductions in CADASIL patients (seed region: right Pcu/CU)
Right PHG	206	−5.62	24	−27	−3	0.005
Left PHG	171	−4.59	−18	−39	−12	0.011
Right postcentral gyrus	115	−4.14	33	−39	57	0.044

The ReHo clusters and seed-based FC that survived were assigned thresholds of p < 0.001 and FWE-corrected to p < 0.05 at the cluster level
ReHo Regional homogeneity, FC Functional connectivity, CADASIL Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, MNI Montreal Neurological Institute, FWE Family wise errors, Pcu/CU Precuneus and cuneus, PHG Parahippocampa gyrus

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