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Table 1 Summary of cardiovascular risk factors, other risk factors, and laboratory values and vital signs at baseline by sex

From: Lasmiditan for acute treatment of migraine in patients with cardiovascular risk factors: post-hoc analysis of pooled results from 2 randomized, double-blind, placebo-controlled, phase 3 trials

Characteristic (unit) Females
(N = 3726)
n (%)
Males
(N = 713)
n (%)
Pooled
(N = 4439)
n (%)
CVRFs per ACC/AHA recommended variablesa
 Age > 40 years 2044 (54.9) 387 (54.3) 2431 (54.8)
 Current smoker 490 (13.2) 139 (19.5) 629 (14.2)
 High total cholesterol (≥ 240 mg/dL) 421 (11.3) 70 (9.8) 491 (11.1)
 Low HDL cholesterol (<  40 mg/dL in men, <  50 mg/dL in women) 1197 (32.1) 206 (28.9) 1403 (31.6)
 High blood pressure (SBP ≥ 140 mmHg and/or medical history of hypertension at baseline) 775 (20.8) 200 (28.1) 975 (22.0)
 Medical history of diabetes mellitus, total 215 (5.8) 53 (7.4) 268 (6.0)
  Type 1 8 (0.2) 2 (0.3) 10 (0.2)
  Type 2 154 (4.1) 31 (4.3) 185 (4.2)
  Type unspecified 53 (1.4) 20 (2.8) 73 (1.6)
Number of CVRFs
 ≥1 2939 (78.9) 561 (78.7) 3500 (78.8)
 ≥2 1507 (40.4) 326 (45.7) 1833 (41.3)
 ≥3 545 (14.6) 125 (17.5) 670 (15.1)
 ≥4 133 (3.6) 36 (5.0) 169 (3.8)
 ≥5 18 (0.5) 7 (1.0) 25 (0.6)
 ≥6 0 (0.0) 0 (0.0) 0 (0.0)
Other risk factors of potential interest
 Postmenopausal 573 (15.4) N/A N/A
 Obese (BMI ≥ 30 kg/m2) 1655 (44.4) 278 (39.0) 1933 (43.5)
 History of migraine with aura 1495 (40.1) 264 (37.0) 1759 (39.6)
 High LDL cholesterol (≥ 160 mg/dL) 245 (6.6) 46 (6.5) 291 (6.6)
 Medical history of hypertension 569 (15.3) 134 (18.8) 703 (15.8)
 Family history of CAD 1134 (30.4) 160 (22.4) 1294 (29.2)
Laboratory values and vital signs, mean (SD)
 Total cholesterol (mg/dL) 192.0 (39.4) 190.6 (38.3) 191.8 (39.3)
  HDL cholesterol 58.0 (16.1) 48.3 (14.6) 56.4 (16.2)
  LDL cholesterol 107.7 (33.3) 109.9 (32.8) 108.1 (33.3)
 SBP (mm Hg) 120.0 (13.9) 127.5 (12.9) 121.2 (14.0)
  1. aACC/AHA guideline-recommended variables for CV risk assessment in adults without diagnosed disease [45]
  2. ACC/AHA American College of Cardiology/American Heart Association, BMI Body mass index, CAD Coronary artery disease, CV Cardiovascular, CVRF Cardiovascular risk factor, HDL High-density lipoprotein, LDL Low-density lipoprotein, N total number of patients in each group, n number of patients with risk factor, N/A Not applicable, SBP Systolic blood pressure, SD Standard deviation