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Table 1 Summary of cardiovascular risk factors, other risk factors, and laboratory values and vital signs at baseline by sex

From: Lasmiditan for acute treatment of migraine in patients with cardiovascular risk factors: post-hoc analysis of pooled results from 2 randomized, double-blind, placebo-controlled, phase 3 trials

Characteristic (unit)

Females

(N = 3726)

n (%)

Males

(N = 713)

n (%)

Pooled

(N = 4439)

n (%)

CVRFs per ACC/AHA recommended variablesa

 Age > 40 years

2044 (54.9)

387 (54.3)

2431 (54.8)

 Current smoker

490 (13.2)

139 (19.5)

629 (14.2)

 High total cholesterol (≥ 240 mg/dL)

421 (11.3)

70 (9.8)

491 (11.1)

 Low HDL cholesterol (<  40 mg/dL in men, <  50 mg/dL in women)

1197 (32.1)

206 (28.9)

1403 (31.6)

 High blood pressure (SBP ≥ 140 mmHg and/or medical history of hypertension at baseline)

775 (20.8)

200 (28.1)

975 (22.0)

 Medical history of diabetes mellitus, total

215 (5.8)

53 (7.4)

268 (6.0)

  Type 1

8 (0.2)

2 (0.3)

10 (0.2)

  Type 2

154 (4.1)

31 (4.3)

185 (4.2)

  Type unspecified

53 (1.4)

20 (2.8)

73 (1.6)

Number of CVRFs

 ≥1

2939 (78.9)

561 (78.7)

3500 (78.8)

 ≥2

1507 (40.4)

326 (45.7)

1833 (41.3)

 ≥3

545 (14.6)

125 (17.5)

670 (15.1)

 ≥4

133 (3.6)

36 (5.0)

169 (3.8)

 ≥5

18 (0.5)

7 (1.0)

25 (0.6)

 ≥6

0 (0.0)

0 (0.0)

0 (0.0)

Other risk factors of potential interest

 Postmenopausal

573 (15.4)

N/A

N/A

 Obese (BMI ≥ 30 kg/m2)

1655 (44.4)

278 (39.0)

1933 (43.5)

 History of migraine with aura

1495 (40.1)

264 (37.0)

1759 (39.6)

 High LDL cholesterol (≥ 160 mg/dL)

245 (6.6)

46 (6.5)

291 (6.6)

 Medical history of hypertension

569 (15.3)

134 (18.8)

703 (15.8)

 Family history of CAD

1134 (30.4)

160 (22.4)

1294 (29.2)

Laboratory values and vital signs, mean (SD)

 Total cholesterol (mg/dL)

192.0 (39.4)

190.6 (38.3)

191.8 (39.3)

  HDL cholesterol

58.0 (16.1)

48.3 (14.6)

56.4 (16.2)

  LDL cholesterol

107.7 (33.3)

109.9 (32.8)

108.1 (33.3)

 SBP (mm Hg)

120.0 (13.9)

127.5 (12.9)

121.2 (14.0)

  1. aACC/AHA guideline-recommended variables for CV risk assessment in adults without diagnosed disease [45]
  2. ACC/AHA American College of Cardiology/American Heart Association, BMI Body mass index, CAD Coronary artery disease, CV Cardiovascular, CVRF Cardiovascular risk factor, HDL High-density lipoprotein, LDL Low-density lipoprotein, N total number of patients in each group, n number of patients with risk factor, N/A Not applicable, SBP Systolic blood pressure, SD Standard deviation