Table 1 Comparison of several features of c-Fos and pERK expression (Adapted from [152]). IHC, immunohistochemistry
From: Animal models of migraine and experimental techniques used to examine trigeminal sensory processing
| Â | c-Fos | pERK |
|---|---|---|
Methods of detection | IHC | IHC |
Mechanism of detection | Gene expression | Phosphorylation |
Induction by noxious stimuli | Yes | Yes |
Induction by innocuous stimuli | Sometimes | No |
Stimulus intensity-dependent | Yes | Yes |
Subcellular distribution in neurons | Nucleus | Nucleus, cytoplasm, dendrites, axons |
Time course after formalin injection | ||
 Onset | 30 min-1 h | 1-3 min |
 Peak induction | 1-2 h | 2-10 min |
 Return to base | 8-24 h | 1-2 h |