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Fig. 5 | The Journal of Headache and Pain

Fig. 5

From: Electrical stimulation of the superior sagittal sinus suppresses A-type K+ currents and increases P/Q- and T-type Ca2+ currents in rat trigeminal ganglion neurons

Fig. 5

ES increased P/Q-type HVA channel currents in small-sized IB4 subpopulation of TG neurons. a and b, Representative current traces (a) and a summary of the results (b) demonstrating that ES significantly increased high voltage-activated (HVA) channel currents in the small-sized IB4 subpopulations of TG neurons but not in small-sized IB4+ TG neurons. *p < 0.05 vs. sham, unpaired t-test. To measure the HVA channel currents, neurons were held at − 60 mV and depolarized to 0 mV (10 mV increments) for 200 ms. c and d, The current densities of total and individual HVA channel subtypes at 0 mV in both the small-sized IB4 (c) and IB4+ (d) subpopulations of TG neurons in the sham and ES-treated groups. The whole-cell IBa through individual HVA channels in small-sized TG neurons was dissected by cumulatively applying 10 μM nifedipine, 2 μM ω-conotoxin-GVIA and 0.5 μM ω-agatoxin-IVA. The remaining Cd2+-sensitive currents were considered R-type currents. *p < 0.05 vs. sham, unpaired t-test

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