Hours after dosing | Lasmiditan dose (mg) | Using preventives | Not using preventives | Interaction p-valueb | ||
---|---|---|---|---|---|---|
Pain freedom n/N (%) | Odds ratioa (CI) | Pain freedom n/N (%) | Odds ratioa (CI) | |||
0.5 | PBO | 2/196 (1.0) | 13/867 (1.5) | |||
50 | 2/104 (1.9) | 1.9 (0.2, 20.9) | 9/452 (2.0) | 1.3 (0.5,3.4) | 0.714 | |
100 | 2/175 (1.1) | 1.2 (0.2, 8.2) | 14/860 (1.6) | 1.1 (0.5,2.3) | 0.904 | |
200 | 3/167 (1.8) | 1.8 (0.3, 10.7) | 22/879 (2.5) | 1.7 (0.8, 3.4) | 0.920 | |
1.0 | PBO | 7/196 (3.6) | 67/867 (7.7) | |||
50 | 7/104 (6.7) | 2.2 (0.6, 8.9) | 33/452 (7.3) | 0.9 (0.5, 1.5) | 0.316 | |
100 | 13/175 (7.4) | 2.2 (0.8, 5.6) | 91/860 (10.6) | 1.4 (1.0, 2.0) | 0.854 | |
200 | 18/167 (10.8) | 3.3 (1.3, 8.0) | 144/879 (16.4) | 2.3 (1.7, 3.2) | 0.889 | |
1.5 | PBO | 13/196 (6.6) | 114/867 (13.1) | |||
50 | 17/104 (16.3) | 2.5 (1.0, 6.3) | 83/452 (18.4) | 1.3 (0.9, 1.8) | 0.196 | |
100 | 28/175 (16.0) | 2.7 (1.3, 5.3) | 188/860 (21.9) | 1.8 (1.4, 2.4) | 0.732 | |
200 | 31/167 (18.6) | 3.2 (1.6, 6.4) | 249/879 (28.3) | 2.6 (2.0, 3.3) | 0.656 | |
2.0 | PBO | 23/196 (11.7) | 172/867 (19.8) | |||
50 | 25/104 (24.0) | 2.2 (1.0, 4.7) | 134/452 (29.6) | 1.4 (1.0, 1.9) | 0.715 | |
100 | 44/175 (25.1) | 2.5 (1.4, 4.4) | 265/860 (30.8) | 1.8 (1.4, 2.2) | 0.654 | |
200 | 51/167 (30.5) | 3.3 (1.9, 5.7) | 321/879 (36.5) | 2.3 (1.9, 2.9) | 0.550 |