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Fig. 1 | The Journal of Headache and Pain

Fig. 1

From: Aura and Stroke: relationship and what we have learnt from preclinical models

Fig. 1

The interplay between migraine and stroke. Shared genetic factors and associated clinical features commonly observed in migraine patients contribute to the link between migraine and stroke. The underlying mechanism involves facilitation of spreading depolarization (SD), the electrophysiological correlate of aura, via increased SD trigger factors and/or reduced threshold for SD induction. SD then causes migraine as well as neuroinflammation and vascular dysfunction, increasing the brain’s vulnerability to ischemia. This cascade may result in clinically silent ischemic lesions that are frequently observed in migraineurs, or even cause ischemic stroke

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