Fig. 8

Secondary amines metabolic profile. From left to right, in the first column there is the list of drug metabolizing enzymes, one for each row; in the second and third columns relationship between corresponding enzyme of the row and different Tricyclic: is indicated by the symbol ‘S’ for substrate, ‘Inh’ for inhibitor and ‘Ind’ for inducer. Enzyme 2D6 is rimmed to emphasize their importance in these secondary amines’ metabolic destiny. Related page at the website http://bioinformatics.charite.de/transformer