Fig. 5
From: Optimising migraine treatment: from drug-drug interactions to personalized medicine
Tramadol metabolic profile. In the left column there is the list of drug metabolizing enzymes and drug transporters, one for each row; in the right column relationship between corresponding transporter or enzyme of the row and tramadol: is indicated by the symbol ‘S’ for substrate and ‘Inh’ for inhibitor. Enzyme CYP2D6 is rimmed to emphasize its importance in tramadol’s metabolic destiny. Related page at the website http://bioinformatics.charite.de/transformer